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Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis
Chen, YZ; Hua, SY; Guo, Z; Fu, H; Wang, CA
Corresponding AuthorChen, YZ()
1999-02-01
Source PublicationPROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
ISSN1002-0071
Volume9Issue:2Pages:81-87
AbstractThe genomic mechanism of steroid hormone action has been widely accepted in endocrinology. But there are difficulties in interpreting the rapid action of steroid hormone on nervous system. The non-genomic mode of glucocorticoid (GC) action was raised in 1987, which proposed that GC acted on the membrane receptor of the neuron. A series of experiments showed that through the non-genomic mechanism, GC could depress the excitability, inhibit the secretion, and augment the uptake of glutamate of neurons. The effects are mediated by the proposed membrane receptor of GC, the existence of which was substantiated by electrophysiological, biochemical, and morphological evidences.
Keywordmembrane receptor glucocorticoid non-genomic mechanism neuron hypothesis
Indexed BySCI
Language英语
WOS Research AreaMaterials Science ; Science & Technology - Other Topics
WOS SubjectMaterials Science, Multidisciplinary ; Multidisciplinary Sciences
WOS IDWOS:000078393200001
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/109156
Collection中国科学院金属研究所
Corresponding AuthorChen, YZ
AffiliationSecond Mil Med Univ, Dept Physiol, Inst Neurosci, Shanghai 200433, Peoples R China
Recommended Citation
GB/T 7714
Chen, YZ,Hua, SY,Guo, Z,et al. Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,1999,9(2):81-87.
APA Chen, YZ,Hua, SY,Guo, Z,Fu, H,&Wang, CA.(1999).Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,9(2),81-87.
MLA Chen, YZ,et al."Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL 9.2(1999):81-87.
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