A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia

doi:10.1179/17535557B15Y.000000010

IMR OpenIR

	A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia
	Zhang, Y.1; Zhang, Q.1,2; Che, E. X.1; Xia, D. D.1; Liu, Y. C.1; Li, D.3; Zhang, Z. D.3; Wang, S. L.1
通讯作者	Wang, S. L.(wangslsy@163.com)
	2015
发表期刊	MATERIALS TECHNOLOGY
ISSN	1066-7857
卷号	30 期号:B4 页码:B211-B215
摘要	A magnetic mesoporous silicon (MMS) composite with magnetic particles as the core and mesoporous as the shell was prepared. The MMS composite was characterised by means of transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen adsorption. The MMS composite with the pore-size of 2 and 200 nm in diameter had a good application prospect in the magnetic-induction hyperthermia and drug delivery. The composite function of magnetic-induction hyperthermia was measured by a high-frequency-induction heating machine with the frequency 608 kHz and the field amplitude 6.4 kA m(-1). The magnetic mesoporous composite took about 7 min to heat up 45 degrees C with the average heating rate of 2.25 degrees C min(-1). The function of loading doxorubicin (DOX) hydrochloride was measured at 488 nm on a UV-Vis spectrophotometry, and the loading efficiency with 20.1% was achieved for the DOX hydrochloride being possibly loaded into the mesoporous. This result put MMS a way of the synchronised therapy of hyperthermia and magnetic target drug delivery.
关键词	Magnetic particles Mesoporous silicon Magnetic heat Synchronised therapy
资助者	National Natural Foundation of China ; Doctor Start-up Program of Liao Ning Province
DOI	10.1179/17535557B15Y.000000010
收录类别	SCI
语种	英语
资助项目	National Natural Foundation of China[81401501] ; Doctor Start-up Program of Liao Ning Province[20111136]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000374566400004
出版者	TAYLOR & FRANCIS LTD
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/122181
专题	中国科学院金属研究所
通讯作者	Wang, S. L.
作者单位	1.Shen Yang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang Pharmaceut Univ, 103 Wenhua Rd, Shenyang 110016, Peoples R China 2.Jiangsu Hengrui Med Co Ltd, Lianyungang 222000, Peoples R China 3.Chinese Acad Sci, Int Ctr Mat Phys, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Y.,Zhang, Q.,Che, E. X.,et al. A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia[J]. MATERIALS TECHNOLOGY,2015,30(B4):B211-B215.
APA	Zhang, Y..,Zhang, Q..,Che, E. X..,Xia, D. D..,Liu, Y. C..,...&Wang, S. L..(2015).A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia.MATERIALS TECHNOLOGY,30(B4),B211-B215.
MLA	Zhang, Y.,et al."A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia".MATERIALS TECHNOLOGY 30.B4(2015):B211-B215.