Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications

doi:10.1177/1721727X16677763

IMR OpenIR

	Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications
	Wang, Yongping 1,2; Zhu, Zhaojin 1; Xu, Xiangyang 1; He, Yaohua 3; Zhang, Bingchun 4
通讯作者	Xu, Xiangyang(xuxy664531@163.com)
	2016-12-01
发表期刊	EUROPEAN JOURNAL OF INFLAMMATION
ISSN	1721-727X
卷号	14 期号:3 页码:169-183
摘要	In this study a calcium phosphate (Ca-P) coating was fabricated on the surface of an AZ31 alloy by a chemical deposition process, and the in vitro and in vivo studies were carried out on a Ca-P-coated and uncoated AZ31 alloy to determine the effect of Ca-P coating on the corrosion behavior and biocompatibility of the AZ31 alloy. The morphology and composition of the Ca-P coating were characterized by scanning electron microscopy and energy dispersive spectroscopy. The corrosion behavior of the Ca-P coating was evaluated by a static immersion test and the effects of the Ca-P coating on biocompatibility were also investigated by in vitro cell experiments and in vivo animal experiments. The results indicated that the Ca-P coating reduced the in vitro and in vivo corrosion rates of the AZ31 alloy. Cell experiments showed significantly good adherence and high proliferation on the Ca-P-coated AZ31 alloy than those on the uncoated AZ31 alloy (P < 0.05). The blood cell aggregation tests showed that the Ca-P-coated AZ31 alloy had decreased the blood cell aggregation compared to the uncoated AZ31 alloy. The animal experiments showed that the uncoated AZ31 alloy degraded more rapidly than the Ca-P-coated AZ31 alloy and the Ca-P coating provided significantly good biocompatibility, thus suggesting that the Ca-P coating not only slowed down the corrosion rate of the AZ31 alloy, but also improved its biocompatibility. Therefore, the Ca-P-coated AZ31 alloy can be considered as a promising biomaterial for orthopedic applications.
关键词	biocompatibility calcium phosphate coating corrosion resistance degradation magnesium alloy
资助者	First Hospital Research Project of Lanzhou University ; National Natural Science Foundation of China
DOI	10.1177/1721727X16677763
收录类别	SCI
语种	英语
资助项目	First Hospital Research Project of Lanzhou University[LDYYYN2013-01] ; National Natural Science Foundation of China[81271961] ; National Natural Science Foundation of China[81572106]
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000389741000003
出版者	SAGE PUBLICATIONS INC
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/123370
专题	中国科学院金属研究所
通讯作者	Xu, Xiangyang
作者单位	1.Shanghai Jiao Tong Univ, Dept Orthoped, Sch Med, Affiliated Ruijin Hosp, Shanghai, Peoples R China 2.Lanzhou Univ, Dept Orthopaed, Hosp 1, Lanzhou, Peoples R China 3.Shanghai Jiao Tong Univ, Dept Orthopaed, Peoples Hosp 6, Shanghai, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yongping,Zhu, Zhaojin,Xu, Xiangyang,et al. Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications[J]. EUROPEAN JOURNAL OF INFLAMMATION,2016,14(3):169-183.
APA	Wang, Yongping,Zhu, Zhaojin,Xu, Xiangyang,He, Yaohua,&Zhang, Bingchun.(2016).Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications.EUROPEAN JOURNAL OF INFLAMMATION,14(3),169-183.
MLA	Wang, Yongping,et al."Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications".EUROPEAN JOURNAL OF INFLAMMATION 14.3(2016):169-183.