| Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications | |
| Wang, Yongping1,2; Zhu, Zhaojin1; Xu, Xiangyang1; He, Yaohua3; Zhang, Bingchun4 | |
| Corresponding Author | Xu, Xiangyang(xuxy664531@163.com) |
| 2016-12-01 | |
| Source Publication | EUROPEAN JOURNAL OF INFLAMMATION
 |
| ISSN | 1721-727X |
| Volume | 14Issue:3Pages:169-183 |
| Abstract | In this study a calcium phosphate (Ca-P) coating was fabricated on the surface of an AZ31 alloy by a chemical deposition process, and the in vitro and in vivo studies were carried out on a Ca-P-coated and uncoated AZ31 alloy to determine the effect of Ca-P coating on the corrosion behavior and biocompatibility of the AZ31 alloy. The morphology and composition of the Ca-P coating were characterized by scanning electron microscopy and energy dispersive spectroscopy. The corrosion behavior of the Ca-P coating was evaluated by a static immersion test and the effects of the Ca-P coating on biocompatibility were also investigated by in vitro cell experiments and in vivo animal experiments. The results indicated that the Ca-P coating reduced the in vitro and in vivo corrosion rates of the AZ31 alloy. Cell experiments showed significantly good adherence and high proliferation on the Ca-P-coated AZ31 alloy than those on the uncoated AZ31 alloy (P < 0.05). The blood cell aggregation tests showed that the Ca-P-coated AZ31 alloy had decreased the blood cell aggregation compared to the uncoated AZ31 alloy. The animal experiments showed that the uncoated AZ31 alloy degraded more rapidly than the Ca-P-coated AZ31 alloy and the Ca-P coating provided significantly good biocompatibility, thus suggesting that the Ca-P coating not only slowed down the corrosion rate of the AZ31 alloy, but also improved its biocompatibility. Therefore, the Ca-P-coated AZ31 alloy can be considered as a promising biomaterial for orthopedic applications. |
| Keyword | biocompatibility calcium phosphate coating corrosion resistance degradation magnesium alloy |
| Funding Organization | First Hospital Research Project of Lanzhou University ; National Natural Science Foundation of China |
| DOI | 10.1177/1721727X16677763 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | First Hospital Research Project of Lanzhou University[LDYYYN2013-01] ; National Natural Science Foundation of China[81271961] ; National Natural Science Foundation of China[81572106] |
| WOS Research Area | Immunology |
| WOS Subject | Immunology |
| WOS ID | WOS:000389741000003 |
| Publisher | SAGE PUBLICATIONS INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/123370 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Xu, Xiangyang |
| Affiliation | 1.Shanghai Jiao Tong Univ, Dept Orthoped, Sch Med, Affiliated Ruijin Hosp, Shanghai, Peoples R China 2.Lanzhou Univ, Dept Orthopaed, Hosp 1, Lanzhou, Peoples R China 3.Shanghai Jiao Tong Univ, Dept Orthopaed, Peoples Hosp 6, Shanghai, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Yongping,Zhu, Zhaojin,Xu, Xiangyang,et al. Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications[J]. EUROPEAN JOURNAL OF INFLAMMATION,2016,14(3):169-183. |
| APA | Wang, Yongping,Zhu, Zhaojin,Xu, Xiangyang,He, Yaohua,&Zhang, Bingchun.(2016).Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications.EUROPEAN JOURNAL OF INFLAMMATION,14(3),169-183. |
| MLA | Wang, Yongping,et al."Improved corrosion resistance and biocompatibility of a calcium phosphate coating on a magnesium alloy for orthopedic applications".EUROPEAN JOURNAL OF INFLAMMATION 14.3(2016):169-183. |
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