| Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves | |
| Li, Bo-han1,2; Yang, Ke3; Wang, Xiao4 | |
| Corresponding Author | Wang, Xiao(bysywangxiao@163.com) |
| 2016-12-01 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 11Issue:12Pages:2012-2017 |
| Abstract | Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. The numbers of cross section nerve fibers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immunofluorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve after Mg treatment. Our findings confirm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves. |
| Keyword | nerve regeneration peripheral nerve regeneration biodegradable magnesium wire sciatic nerve rats nerve growth factor P75 neurotrophin receptor tyrosine receptor kinase A neural regeneration |
| Funding Organization | National Natural Science Foundation of China ; China Postdoctoral Science Foundation |
| DOI | 10.4103/1673-5374.197146 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81400528] ; China Postdoctoral Science Foundation[20130390827] |
| WOS Research Area | Cell Biology ; Neurosciences & Neurology |
| WOS Subject | Cell Biology ; Neurosciences |
| WOS ID | WOS:000393890900029 |
| Publisher | MEDKNOW PUBLICATIONS & MEDIA PVT LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/123759 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Wang, Xiao |
| Affiliation | 1.Gen Hosp Peoples Liberat Army, Dept Oral Maxillofacial Surg, Beijing, Peoples R China 2.Binzhou Med Univ, Dept Oral Maxillofacial Surg, Yantai, Shandong, Peoples R China 3.Chinese Acad Sci, Met Res Inst, Shenyang, Liaoning Provin, Peoples R China 4.Peking Univ, Hosp 3, Dept Oral & Maxillofacial Surg, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Bo-han,Yang, Ke,Wang, Xiao. Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves[J]. NEURAL REGENERATION RESEARCH,2016,11(12):2012-2017. |
| APA | Li, Bo-han,Yang, Ke,&Wang, Xiao.(2016).Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.NEURAL REGENERATION RESEARCH,11(12),2012-2017. |
| MLA | Li, Bo-han,et al."Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves".NEURAL REGENERATION RESEARCH 11.12(2016):2012-2017. |
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