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Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves
Li, Bo-han1,2; Yang, Ke3; Wang, Xiao4
Corresponding AuthorWang, Xiao(bysywangxiao@163.com)
2016-12-01
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume11Issue:12Pages:2012-2017
AbstractMagnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. The numbers of cross section nerve fibers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immunofluorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve after Mg treatment. Our findings confirm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves.
Keywordnerve regeneration peripheral nerve regeneration biodegradable magnesium wire sciatic nerve rats nerve growth factor P75 neurotrophin receptor tyrosine receptor kinase A neural regeneration
Funding OrganizationNational Natural Science Foundation of China ; China Postdoctoral Science Foundation
DOI10.4103/1673-5374.197146
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81400528] ; China Postdoctoral Science Foundation[20130390827]
WOS Research AreaCell Biology ; Neurosciences & Neurology
WOS SubjectCell Biology ; Neurosciences
WOS IDWOS:000393890900029
PublisherMEDKNOW PUBLICATIONS & MEDIA PVT LTD
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/123759
Collection中国科学院金属研究所
Corresponding AuthorWang, Xiao
Affiliation1.Gen Hosp Peoples Liberat Army, Dept Oral Maxillofacial Surg, Beijing, Peoples R China
2.Binzhou Med Univ, Dept Oral Maxillofacial Surg, Yantai, Shandong, Peoples R China
3.Chinese Acad Sci, Met Res Inst, Shenyang, Liaoning Provin, Peoples R China
4.Peking Univ, Hosp 3, Dept Oral & Maxillofacial Surg, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, Bo-han,Yang, Ke,Wang, Xiao. Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves[J]. NEURAL REGENERATION RESEARCH,2016,11(12):2012-2017.
APA Li, Bo-han,Yang, Ke,&Wang, Xiao.(2016).Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.NEURAL REGENERATION RESEARCH,11(12),2012-2017.
MLA Li, Bo-han,et al."Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves".NEURAL REGENERATION RESEARCH 11.12(2016):2012-2017.
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