Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes

doi:10.11900/0412.1961.2017.00279

IMR OpenIR

	Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes
	Dong Jiahui 1,2; Tan Lili 1; Yang Ke 1
通讯作者	Yang Ke(kyang@imr.ac.cn)
	2017-10-11
发表期刊	ACTA METALLURGICA SINICA
ISSN	0412-1961
卷号	53 期号:10 页码:1197-1206
摘要	Bone defects are very challenging in orthopedic practice due to a variety of reasons. Bone repair requires four critical elements, biocompatibility, osteoconduction, osteoinduction and osteogenesis. The autografts still exist some problems for applications such as the limitation of available autogenous bones and post-operative complications, although they are considered as the "gold standard" in bony defect repairs. Generally the synthetic bone substitutes do not possess osteoinductive and osteogenic activities. Therefore, the clinical bone grafts and bone-graft substitutes have their own shortcomings in the repair of bone defects. Biodegradable magnesium-based metals, including pure magnesium and magnesium alloys, have been concerned and studied recently due to their biodegradation, good biocompatibility and similar elastic modulus and density with bone tissue. This paper summarizes the biological behavior of magnesium-based metals for bone defects repair application, including ability of promoting osteogenesis, osteoconduction and potential osteoinduction, as well as some particular biofunctions such as antibacterial and antitumor properties. The great advantages and potentials of magnesium in bone defects repair can not be denied as a promising class of bone substitutes, although further researches are still needed for clinical applications.
关键词	bone defect bone repair osteogenesis Mg-based metal biodegradable
资助者	National Natural Science Foundation of China
DOI	10.11900/0412.1961.2017.00279
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81401773] ; National Natural Science Foundation of China[31500777]
WOS研究方向	Metallurgy & Metallurgical Engineering
WOS类目	Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000416301400005
出版者	SCIENCE PRESS
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/125459
专题	中国科学院金属研究所
通讯作者	Yang Ke
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Dong Jiahui,Tan Lili,Yang Ke. Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes[J]. ACTA METALLURGICA SINICA,2017,53(10):1197-1206.
APA	Dong Jiahui,Tan Lili,&Yang Ke.(2017).Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes.ACTA METALLURGICA SINICA,53(10),1197-1206.
MLA	Dong Jiahui,et al."Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes".ACTA METALLURGICA SINICA 53.10(2017):1197-1206.