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Role of placenta-specific protein 1 in trophoblast invasion and migration
Chang, Wen-Lin1,2; Yang, Qing1; Zhang, Hui; Lin, Hai-Yan2,3; Zhou, Zhi2,4; Lu, Xiaoyin2,4; Zhu, Cheng2; Xue, Li-Qun1; Wang, Hongmei2
Corresponding AuthorWang, Hongmei(wanghm@ioz.ac.cn)
2014-10-01
Source PublicationREPRODUCTION
ISSN1470-1626
Volume148Issue:4Pages:343-352
AbstractPlacenta-specific protein 1 (PLAC1), a placenta-specific gene, is known to be involved in the development of placenta in both humans and mice. However, the precise role of PLAC1 in placental trophoblast function remains unclear. In this study, the localization of PLAC1 in human placental tissues and its physiological significance in trophoblast invasion and migration are investigated by technical studies including real-time RT-PCR, in situ hybridization, immunohistochemistry, and functional studies by utilizing cell invasion and migration assays in the trophoblast cell line HTR8/SVneo as well as the primary inducing extravillous trophoblasts (EVTs). The results show that PLAC1 is mainly detected in the trophoblast columns and syncytiotrophoblast of the first-trimester human placental villi, as well as in the EVTs that invade into the maternal decidua. Knockdown of PLAC1 by RNA interference significantly suppresses the invasion and migration of HTR8/SVneo cells and shortens the distance of the outgrowth of the induced EVTs from the cytotrophoblast column of the explants. All the above data suggests that PLAC1 plays an important role in human placental trophoblast invasion and migration.
Funding OrganizationNational Key Basic Research Program of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Natural Science Foundation of China
DOI10.1530/REP-14-0052
Indexed BySCI
Language英语
Funding ProjectNational Key Basic Research Program of China[2011CB944400] ; National Key Basic Research Program of China[2012CB126310] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA01020102] ; Natural Science Foundation of China[81225004] ; Natural Science Foundation of China[31271603] ; Natural Science Foundation of China[31171438]
WOS Research AreaDevelopmental Biology ; Reproductive Biology
WOS SubjectDevelopmental Biology ; Reproductive Biology
WOS IDWOS:000343331100004
PublisherBIOSCIENTIFICA LTD
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/125869
Collection中国科学院金属研究所
Corresponding AuthorWang, Hongmei
Affiliation1.Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
3.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing 100069, Peoples R China
4.Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Chang, Wen-Lin,Yang, Qing,Zhang, Hui,et al. Role of placenta-specific protein 1 in trophoblast invasion and migration[J]. REPRODUCTION,2014,148(4):343-352.
APA Chang, Wen-Lin.,Yang, Qing.,Zhang, Hui.,Lin, Hai-Yan.,Zhou, Zhi.,...&Wang, Hongmei.(2014).Role of placenta-specific protein 1 in trophoblast invasion and migration.REPRODUCTION,148(4),343-352.
MLA Chang, Wen-Lin,et al."Role of placenta-specific protein 1 in trophoblast invasion and migration".REPRODUCTION 148.4(2014):343-352.
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