Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid

doi:10.1021/jp7121467

IMR OpenIR

	Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid
	Liu, Yanyan 1,2; Zhou, Qianxiong 1,2; Zeng, Zhanghua 1,2; Qiao, Rui 1,2; Wang, Xuesong 1; Zhang, Baowen 1
通讯作者	Zhang, Baowen(g203@mail.ipc.ac.cn)
	2008-08-14
发表期刊	JOURNAL OF PHYSICAL CHEMISTRY B
ISSN	1520-6106
卷号	112 期号:32 页码:9959-9965
摘要	The photodynamic properties of a new hypocrellin B (HB) derivative bearing a bispyrrolecarboxamide pendant (HB-Net) were investigated in detail. EPR experiments revealed that the generation ability of reactive oxygen species (ROS) of HB-Net is inferior to that of HB. DNA melting temperature measurements and ethidium bromide (EB) displacement assay illustrated the affinity of HB-Net toward dsDNA as the result of the bispyrrolecarboxamide unit, which is structurally related to the well-known minor groove binder netropsin. The radical generation abilities of HB and HB-Net can be enhanced by ascorbic acid via the photoinduced electron transfer from ascorbic acid to the photosensitizer, however, only the DNA photodamage capability of HB-Net can be improved significantly by ascorbic acid due to the stronger affinity of HB-Net to DNA. Consequently, the combination of HB-Net and ascorbic acid may lead to efficient DNA photodamage even in anaerobic conditions.
DOI	10.1021/jp7121467
收录类别	SCI
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Physical
WOS记录号	WOS:000258290000048
出版者	AMER CHEMICAL SOC
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/126283
专题	中国科学院金属研究所
通讯作者	Zhang, Baowen
作者单位	1.Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Grad Sch Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yanyan,Zhou, Qianxiong,Zeng, Zhanghua,et al. Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(32):9959-9965.
APA	Liu, Yanyan,Zhou, Qianxiong,Zeng, Zhanghua,Qiao, Rui,Wang, Xuesong,&Zhang, Baowen.(2008).Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid.JOURNAL OF PHYSICAL CHEMISTRY B,112(32),9959-9965.
MLA	Liu, Yanyan,et al."Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid".JOURNAL OF PHYSICAL CHEMISTRY B 112.32(2008):9959-9965.