| Research on rat's pulmonary acute injury induced by lunar soil simulant | |
| Sun, Yan1,2; Liu, Jin-Guo2; Zheng, Yong-Chun3; Xiao, Chun-Ling1; Wan, Bing4; Guo, Li1; Wang, Xu-Guang1; Bo, Wei1 | |
| Corresponding Author | Sun, Yan(inksun@163.com) |
| 2018-02-01 | |
| Source Publication | JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
 |
| ISSN | 1726-4901 |
| Volume | 81Issue:2Pages:133-140 |
| Abstract | Background: The steps to the moon never stopped after the Apollo Project. Lessons from manned landings on the moon have shown that lunar dust has great influence on the health of astronauts. In this paper, comparative studies between the lunar soil simulant (LSS) and PM2.5 were performed to discover their harm to human biological systems and explore the methods of prevention and treatment of dust poisoning for future lunar manned landings. Methods: Rats were randomly divided into the control group, two CAS-1 lunar soil simulant groups (tracheal perfusion with 7 mg and 0.7 mg, respectively, in a 1-mL volume) and the PM2.5 group (tracheal perfusion with 0.7 mg in a 1-mL volume). The biochemical indicators in the bronchoalveolar lavage fluid (BALF), MPO activity in the lung tissue, pathologic changes, and inflammatory cells in the BALF were measured after 4 h and 24 h. Results: The LSS group showed cytotoxicity that was closely related to the concentration. The figures of the two LSS groups (4 and 24 h) show that the alveolar septa were thickened. Additionally, it was observed that neutrophils had infiltrated, and various levels of inflammation occurred around the vascular and bronchial structures. Conclusion: The overall results of the acute effects of the lungs caused by dust showed that the lung toxicity of LSS was greater than that of PM2.5. LSS could induce lung damage and inflammatory lesions. The biomarkers in BALF caused by acute injury were consistent with his-topathologi c observations. Copyright (C) 2017, the Chinese Medical Association. Published by Elsevier Taiwan LLC. |
| Keyword | Acute injury Lunar soil simulant Lung Rat |
| Funding Organization | Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau |
| DOI | 10.1016/j.jcma.2016.10.016 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Science and Technology Research Fund of Shenyang Medical College[20171020] ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department[20170520437] ; National Science Foundation of China[51775541] ; Research Fund of China Manned Space Engineering[030201] ; Science and Technology Development Fund of Macau[020/2014/A1] |
| WOS Research Area | General & Internal Medicine |
| WOS Subject | Medicine, General & Internal |
| WOS ID | WOS:000425706600008 |
| Publisher | ELSEVIER TAIWAN |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/127339 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Sun, Yan |
| Affiliation | 1.Shenyang Med Coll, Huanghebei St 146, Shenyang, Liaoning, Peoples R China 2.Chinese Acad Sci, Shenyang Inst Automat, State Key Lab Robot, Shenyang, Liaoning, Peoples R China 3.Chinese Acad Sci, Natl Astron Observ, Beijing, Peoples R China 4.Shenyang Med Coll, Cent Hosp, Lab Med, Shenyang, Liaoning, Peoples R China |
| Recommended Citation GB/T 7714 | Sun, Yan,Liu, Jin-Guo,Zheng, Yong-Chun,et al. Research on rat's pulmonary acute injury induced by lunar soil simulant[J]. JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,2018,81(2):133-140. |
| APA | Sun, Yan.,Liu, Jin-Guo.,Zheng, Yong-Chun.,Xiao, Chun-Ling.,Wan, Bing.,...&Bo, Wei.(2018).Research on rat's pulmonary acute injury induced by lunar soil simulant.JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,81(2),133-140. |
| MLA | Sun, Yan,et al."Research on rat's pulmonary acute injury induced by lunar soil simulant".JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 81.2(2018):133-140. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment