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In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect
Dong, Jiahui1,2; Tan, Lili1; Yang, Jiahui3; Wang, Yongxuan3; Chen, Junxiu1,2; Wang, Weidan1; Zhao, Dewei3; Yang, Ke1
Corresponding AuthorTan, Lili(lltan@imr.ac.cn) ; Zhao, Dewei(zhaodewei2000@163.com)
2018
Source PublicationMATERIALS TECHNOLOGY
ISSN1066-7857
Volume33Issue:6Pages:387-397
AbstractMg-Sr alloy is considered as a promising biodegradable bone repair material. However, its poor corrosion resistance limits its clinical application. In this study, the corrosion rate of Mg-Sr alloy was greatly improved through the heat treatment. Both in vitro and in vivo corrosion tests (immersion and electrochemical test) showed that corrosion resistance of Mg-Sr alloy was enhanced. In the animal test (New Zealand rabbit), both micro-CT analysis and Van Gieson staining demonstrated that the treated Mg-Sr alloy implant exhibited better osteogenesis and osteointegration ability, which accelerate the healing of bone defect. The results indicate that the treated Mg-Sr alloy has great possibility and potential for application as a new bone repair material.
KeywordMg-Sr alloy bone defect heat treatment bone response
Funding OrganizationKey Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials ; National Natural Science Foundation of China ; Institute of Metal Research, Chinese Academy of Sciences
DOI10.1080/10667857.2018.1452587
Indexed BySCI
Language英语
Funding ProjectKey Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials ; National Natural Science Foundation of China[31500777] ; Institute of Metal Research, Chinese Academy of Sciences[2015-ZD01]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000430487300001
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/127771
Collection中国科学院金属研究所
Corresponding AuthorTan, Lili; Zhao, Dewei
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang, Liaoning, Peoples R China
3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Orthoped, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Dong, Jiahui,Tan, Lili,Yang, Jiahui,et al. In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect[J]. MATERIALS TECHNOLOGY,2018,33(6):387-397.
APA Dong, Jiahui.,Tan, Lili.,Yang, Jiahui.,Wang, Yongxuan.,Chen, Junxiu.,...&Yang, Ke.(2018).In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect.MATERIALS TECHNOLOGY,33(6),387-397.
MLA Dong, Jiahui,et al."In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect".MATERIALS TECHNOLOGY 33.6(2018):387-397.
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