| In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect | |
| Dong, Jiahui1,2; Tan, Lili1; Yang, Jiahui3; Wang, Yongxuan3; Chen, Junxiu1,2; Wang, Weidan1; Zhao, Dewei3; Yang, Ke1 | |
| Corresponding Author | Tan, Lili(lltan@imr.ac.cn) ; Zhao, Dewei(zhaodewei2000@163.com) |
| 2018 | |
| Source Publication | MATERIALS TECHNOLOGY
 |
| ISSN | 1066-7857 |
| Volume | 33Issue:6Pages:387-397 |
| Abstract | Mg-Sr alloy is considered as a promising biodegradable bone repair material. However, its poor corrosion resistance limits its clinical application. In this study, the corrosion rate of Mg-Sr alloy was greatly improved through the heat treatment. Both in vitro and in vivo corrosion tests (immersion and electrochemical test) showed that corrosion resistance of Mg-Sr alloy was enhanced. In the animal test (New Zealand rabbit), both micro-CT analysis and Van Gieson staining demonstrated that the treated Mg-Sr alloy implant exhibited better osteogenesis and osteointegration ability, which accelerate the healing of bone defect. The results indicate that the treated Mg-Sr alloy has great possibility and potential for application as a new bone repair material. |
| Keyword | Mg-Sr alloy bone defect heat treatment bone response |
| Funding Organization | Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials ; National Natural Science Foundation of China ; Institute of Metal Research, Chinese Academy of Sciences |
| DOI | 10.1080/10667857.2018.1452587 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials ; National Natural Science Foundation of China[31500777] ; Institute of Metal Research, Chinese Academy of Sciences[2015-ZD01] |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Multidisciplinary |
| WOS ID | WOS:000430487300001 |
| Publisher | TAYLOR & FRANCIS LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/127771 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Tan, Lili; Zhao, Dewei |
| Affiliation | 1.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang, Liaoning, Peoples R China 3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Orthoped, Dalian, Peoples R China |
| Recommended Citation GB/T 7714 | Dong, Jiahui,Tan, Lili,Yang, Jiahui,et al. In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect[J]. MATERIALS TECHNOLOGY,2018,33(6):387-397. |
| APA | Dong, Jiahui.,Tan, Lili.,Yang, Jiahui.,Wang, Yongxuan.,Chen, Junxiu.,...&Yang, Ke.(2018).In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect.MATERIALS TECHNOLOGY,33(6),387-397. |
| MLA | Dong, Jiahui,et al."In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect".MATERIALS TECHNOLOGY 33.6(2018):387-397. |
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