Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity

doi:10.3390/md16040107

IMR OpenIR

	Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity
	Li, Qing 1; Sun, Xueqi 1,2; Gu, Guodong 3; Guo, Zhanyong 1
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
	2018-04-01
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	16 期号:4 页码:13
摘要	Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed for its potential of providing high bioactivity and good water solubility. A new class of chitosan derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. Their free radical-scavenging activity against three free radicals was tested. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that triazole or triazolium groups enable the synthesized chitosan to possess obviously better radical-scavenging activity. Moreover, the scavenging activity against superoxide radical of chitosan derivatives with triazolium (IC50 < 0.01 mg mL(-1)) was more efficient than that of derivatives with triazole and Vitamin C. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical-scavenging assay, the same pattern were observed, which should be related to the triazolium grafted at the periphery of molecular chains.
关键词	chitosan derivatives 1,2,3-triazolium free radical-scavenging activity
资助者	National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province of China ; Yantai Science and Technology Development Plan ; Technology Research Funds Projects of Ocean
DOI	10.3390/md16040107
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41576156] ; Natural Science Foundation of Shandong Province of China[ZR2017BD015] ; Yantai Science and Technology Development Plan[2015ZH078] ; Technology Research Funds Projects of Ocean[2015418022-3]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000431068000009
出版者	MDPI
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/127935
专题	中国科学院金属研究所
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China 2.Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式 GB/T 7714	Li, Qing,Sun, Xueqi,Gu, Guodong,et al. Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity[J]. MARINE DRUGS,2018,16(4):13.
APA	Li, Qing,Sun, Xueqi,Gu, Guodong,&Guo, Zhanyong.(2018).Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity.MARINE DRUGS,16(4),13.
MLA	Li, Qing,et al."Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity".MARINE DRUGS 16.4(2018):13.