| Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system | |
| Lv, Xiaojie1,2; Zhang, Wenchang1; Liu, Yunen3; Zhao, Yan1; Zhang, Jinsong1; Hou, Mingxiao3 | |
| Corresponding Author | Zhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jshzhang@imr.ac.cn) |
| 2018-10-15 | |
| Source Publication | CARBOHYDRATE POLYMERS
 |
| ISSN | 0144-8617 |
| Volume | 198Pages:86-93 |
| Abstract | Polyelectrolyte complex (PECs) hydrogels with high hygroscopicity modulation ability were successfully prepared based on carboxymethyl chitosan (CMCS)/alginate. The swelling ratio of the hydrogels could be tuned from 1 to 450 simply by changing the weight ratio of CMCS to alginate, and superabsorbent hydrogels were obtained when the weight ratio of CMCS to alginate was below 1/1. Also, the swelling kinetics and water diffusion mechanism in the hydrogels were discussed. In vitro cytotoxicity results indicated that hydrogels had excellent cytocompatibility. The swelling ratio of the hydrogel as well as its BSA releasing profile was notably pH dependent. Compared with the values at pH 1.2, the swelling ratio of hydrogels (CMCS/alginate weight ratio of 1/2) at pH 7.4 was about 34 times higher, and the amount of BSA released at pH 7.4 was also significantly higher. The as-prepared CMCS/alginate PECs hydrogels hold great potential for oral delivery of protein drugs through the intestinal tract. |
| Keyword | Polyelectrolyte complex hydrogels pH-sensitive Superabsorbent Electrostatic Interactions Oral drug delivery |
| Funding Organization | National Key Research and Development Plan ; National Natural Science Foundation of China |
| DOI | 10.1016/j.carbpol.2018.06.058 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Plan[2016YFB0301502] ; National Natural Science Foundation of China[U1608255] |
| WOS Research Area | Chemistry ; Polymer Science |
| WOS Subject | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS ID | WOS:000440785200011 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/129003 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhao, Yan; Zhang, Jinsong |
| Affiliation | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Gen Hosp Shenyang Mil Command, Dept Emergency Med, Shenyang 110016, Liaoning, Peoples R China |
| Recommended Citation GB/T 7714 | Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,et al. Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system[J]. CARBOHYDRATE POLYMERS,2018,198:86-93. |
| APA | Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,Zhao, Yan,Zhang, Jinsong,&Hou, Mingxiao.(2018).Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system.CARBOHYDRATE POLYMERS,198,86-93. |
| MLA | Lv, Xiaojie,et al."Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system".CARBOHYDRATE POLYMERS 198(2018):86-93. |
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