Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system

doi:10.1016/j.carbpol.2018.06.058

IMR OpenIR

	Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system
	Lv, Xiaojie 1,2; Zhang, Wenchang 1; Liu, Yunen 3; Zhao, Yan 1; Zhang, Jinsong 1; Hou, Mingxiao 3
通讯作者	Zhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jshzhang@imr.ac.cn)
	2018-10-15
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	198 页码:86-93
摘要	Polyelectrolyte complex (PECs) hydrogels with high hygroscopicity modulation ability were successfully prepared based on carboxymethyl chitosan (CMCS)/alginate. The swelling ratio of the hydrogels could be tuned from 1 to 450 simply by changing the weight ratio of CMCS to alginate, and superabsorbent hydrogels were obtained when the weight ratio of CMCS to alginate was below 1/1. Also, the swelling kinetics and water diffusion mechanism in the hydrogels were discussed. In vitro cytotoxicity results indicated that hydrogels had excellent cytocompatibility. The swelling ratio of the hydrogel as well as its BSA releasing profile was notably pH dependent. Compared with the values at pH 1.2, the swelling ratio of hydrogels (CMCS/alginate weight ratio of 1/2) at pH 7.4 was about 34 times higher, and the amount of BSA released at pH 7.4 was also significantly higher. The as-prepared CMCS/alginate PECs hydrogels hold great potential for oral delivery of protein drugs through the intestinal tract.
关键词	Polyelectrolyte complex hydrogels pH-sensitive Superabsorbent Electrostatic Interactions Oral drug delivery
资助者	National Key Research and Development Plan ; National Natural Science Foundation of China
DOI	10.1016/j.carbpol.2018.06.058
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Plan[2016YFB0301502] ; National Natural Science Foundation of China[U1608255]
WOS研究方向	Chemistry ; Polymer Science
WOS类目	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000440785200011
出版者	ELSEVIER SCI LTD
引用统计	被引频次：79[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/129003
专题	中国科学院金属研究所
通讯作者	Zhao, Yan; Zhang, Jinsong
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Gen Hosp Shenyang Mil Command, Dept Emergency Med, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,et al. Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system[J]. CARBOHYDRATE POLYMERS,2018,198:86-93.
APA	Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,Zhao, Yan,Zhang, Jinsong,&Hou, Mingxiao.(2018).Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system.CARBOHYDRATE POLYMERS,198,86-93.
MLA	Lv, Xiaojie,et al."Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system".CARBOHYDRATE POLYMERS 198(2018):86-93.