IMR OpenIR
Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity
Zhang, Xuejiao1; Lei, Lei1,5; Zhang, Haiyan2; Zhang, Siyu1,4; Xing, Weiwei3; Wang, Jin3; Li, Haibo2,4; Zhao, Qing1; Xing, Baoshan4
Corresponding AuthorZhao, Qing(zhaoqing@iae.ac.cn)
2018-10-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume241Pages:701-709
AbstractAttention has been paid to the environmental distribution and fate of nanomedicines. However, their effects on the toxicity of environmental pollutants are lack of knowledge. In this study, the negatively charged poly (ethylene glycol)-b-poly (L-lactide-co-glycolide) (mPEG-PLA) and positively charged polyethyleneimine-palmitate (PEI-PA) nanomicelles were synthesized and served as model drug carriers to study the interaction and combined toxicity with dichlorodiphenyltrichloroethane (DDT). DDT exerted limited effect on the biointerfacial behavior of mPEG-PLA nanomicelles, whereas it significantly mitigated the attachment of PEI-PA nanomicelles on the model cell membrane as monitored by quartz crystal microbalance with dissipation (QCM-D). The cytotoxicity of DDT towards NIH 3T3 cells was greatly decreased by either co-treatment or pre-treatment with the nanomicelles according to the results of real-time cell analysis (RICA). The cell viability of NIH 3T3 exposed to DDT was increased up to 90% by the co-treatment with mPEG-PLA nanomicelles. Three possible reasons were proposed: (1) decreased amount of free DDT in the cell culture medium due to the partitioning of DDT into nanomicelles; (2) mitigated cellular uptake of nanomicelle-DDT complexes due to the complex agglomeration or electrostatic repulsion between complexes and cell membrane; (3) detoxification effect in the lysosome upon endocytosis of nanomicelle-DDT complexes. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordPolymeric nanomicelles Organic pollutants Partitioning behavior Combined cytotoxicity Biointerfacial behavior
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences
DOI10.1016/j.envpol.2018.06.010
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41603120] ; National Natural Science Foundation of China[41703107] ; National Natural Science Foundation of China[21671115] ; National Key Research and Development Program of China[2016YFD0800300] ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000440390800075
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/129047
Collection中国科学院金属研究所
Corresponding AuthorZhao, Qing
Affiliation1.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang, Liaoning, Peoples R China
2.Northeastern Univ, Sch Resources & Civil Engn, Shenyang 110004, Liaoning, Peoples R China
3.Liaoning Beifang Environm Technol Co LTD, Shenyang 110161, Liaoning, Peoples R China
4.Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA
5.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xuejiao,Lei, Lei,Zhang, Haiyan,et al. Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity[J]. ENVIRONMENTAL POLLUTION,2018,241:701-709.
APA Zhang, Xuejiao.,Lei, Lei.,Zhang, Haiyan.,Zhang, Siyu.,Xing, Weiwei.,...&Xing, Baoshan.(2018).Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity.ENVIRONMENTAL POLLUTION,241,701-709.
MLA Zhang, Xuejiao,et al."Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity".ENVIRONMENTAL POLLUTION 241(2018):701-709.
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