| Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity | |
| Zhang, Xuejiao1; Lei, Lei1,5; Zhang, Haiyan2; Zhang, Siyu1,4; Xing, Weiwei3; Wang, Jin3; Li, Haibo2,4; Zhao, Qing1; Xing, Baoshan4 | |
| Corresponding Author | Zhao, Qing(zhaoqing@iae.ac.cn) |
| 2018-10-01 | |
| Source Publication | ENVIRONMENTAL POLLUTION
 |
| ISSN | 0269-7491 |
| Volume | 241Pages:701-709 |
| Abstract | Attention has been paid to the environmental distribution and fate of nanomedicines. However, their effects on the toxicity of environmental pollutants are lack of knowledge. In this study, the negatively charged poly (ethylene glycol)-b-poly (L-lactide-co-glycolide) (mPEG-PLA) and positively charged polyethyleneimine-palmitate (PEI-PA) nanomicelles were synthesized and served as model drug carriers to study the interaction and combined toxicity with dichlorodiphenyltrichloroethane (DDT). DDT exerted limited effect on the biointerfacial behavior of mPEG-PLA nanomicelles, whereas it significantly mitigated the attachment of PEI-PA nanomicelles on the model cell membrane as monitored by quartz crystal microbalance with dissipation (QCM-D). The cytotoxicity of DDT towards NIH 3T3 cells was greatly decreased by either co-treatment or pre-treatment with the nanomicelles according to the results of real-time cell analysis (RICA). The cell viability of NIH 3T3 exposed to DDT was increased up to 90% by the co-treatment with mPEG-PLA nanomicelles. Three possible reasons were proposed: (1) decreased amount of free DDT in the cell culture medium due to the partitioning of DDT into nanomicelles; (2) mitigated cellular uptake of nanomicelle-DDT complexes due to the complex agglomeration or electrostatic repulsion between complexes and cell membrane; (3) detoxification effect in the lysosome upon endocytosis of nanomicelle-DDT complexes. (C) 2018 Elsevier Ltd. All rights reserved. |
| Keyword | Polymeric nanomicelles Organic pollutants Partitioning behavior Combined cytotoxicity Biointerfacial behavior |
| Funding Organization | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences |
| DOI | 10.1016/j.envpol.2018.06.010 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[41603120] ; National Natural Science Foundation of China[41703107] ; National Natural Science Foundation of China[21671115] ; National Key Research and Development Program of China[2016YFD0800300] ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences |
| WOS Research Area | Environmental Sciences & Ecology |
| WOS Subject | Environmental Sciences |
| WOS ID | WOS:000440390800075 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/129050 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhao, Qing |
| Affiliation | 1.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang, Liaoning, Peoples R China 2.Northeastern Univ, Sch Resources & Civil Engn, Shenyang 110004, Liaoning, Peoples R China 3.Liaoning Beifang Environm Technol Co LTD, Shenyang 110161, Liaoning, Peoples R China 4.Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA 5.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Xuejiao,Lei, Lei,Zhang, Haiyan,et al. Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity[J]. ENVIRONMENTAL POLLUTION,2018,241:701-709. |
| APA | Zhang, Xuejiao.,Lei, Lei.,Zhang, Haiyan.,Zhang, Siyu.,Xing, Weiwei.,...&Xing, Baoshan.(2018).Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity.ENVIRONMENTAL POLLUTION,241,701-709. |
| MLA | Zhang, Xuejiao,et al."Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity".ENVIRONMENTAL POLLUTION 241(2018):701-709. |
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