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Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin
Sun, Ying-Sui1; Huang, Chi-Ya2; Chen, Chiang-Sang3; Chang, Jean-Heng4; Hou, Wen-Tao5; Li, Shu-Jun5; Hao, Yu-Lin5; Pan, Haobo6; Huang, Her-Hsiung1,2,7,8,9,10
Corresponding AuthorHuang, Her-Hsiung(hhhuang@ym.edu.tw)
2018-09-25
Source PublicationSURFACE & COATINGS TECHNOLOGY
ISSN0257-8972
Volume350Pages:918-924
AbstractIn this study, we investigated various responses of human bone marrow mesenchymal stem cells (hMSCs) to a low elastic modulus Ti-24Nb-4Zr-8Sn (Ti2448) alloy surface that underwent immobilization using the natural cross-linker genipin. Specifically, hMSC's adhesion, proliferation, mineralization, and differentiation were evaluated. We also analyzed surface characteristics of the Ti2448 alloy, including chemistry, morphology, roughness, and wettability. Our results suggest that genipin immobilized Ti2448 has the potential to benefit orthopedic and dental implant applications. We found that the immobilization of genipin on a sand-blasted/acid-etched Ti2448 alloy surface significantly enhanced the mineralization of the extracellular matrix as well as the expression of certain osteogenic markers (bone sialoprotein and osteocalcin) in hMSCs. Conversely, surface roughness and hydrophilicity cannot be credited with the improved cellular responses observed in this study. The immobilization of genipin to produce a biomolecular surface on low elastic modulus Ti2448 alloy has considerable potential for bone implant applications.
KeywordLow elastic modulus Ti alloy Immobilization Natural crosslinker Genipin Cell response
Funding OrganizationMinistry of Science and Technology of Taiwan ; Far Eastern Memorial Hospital ; Cheng Hsin General Hospital, Taipei, Taiwan ; Chinese MOST ; Key Research Program of Frontier Sciences, CAS ; National Natural Science Foundation of China ; Shenzhen Peacock Program
DOI10.1016/j.surfcoat.2018.03.069
Indexed BySCI
Language英语
Funding ProjectMinistry of Science and Technology of Taiwan[MOST 104-2221-E-040-003] ; Ministry of Science and Technology of Taiwan[105-2221-E-040-001] ; Far Eastern Memorial Hospital[105FN20] ; Far Eastern Memorial Hospital[106DN19] ; Cheng Hsin General Hospital, Taipei, Taiwan[CY10520] ; Cheng Hsin General Hospital, Taipei, Taiwan[CY10620] ; Chinese MOST[2017YFC1104901] ; Chinese MOST[2016YFC110261] ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-JSC031-02] ; National Natural Science Foundation of China[51591190] ; National Natural Science Foundation of China[51771209] ; National Natural Science Foundation of China[51631007] ; Shenzhen Peacock Program[110811003586331]
WOS Research AreaMaterials Science ; Physics
WOS SubjectMaterials Science, Coatings & Films ; Physics, Applied
WOS IDWOS:000444660500095
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/129485
Collection中国科学院金属研究所
Corresponding AuthorHuang, Her-Hsiung
Affiliation1.Natl Yang Ming Univ, Dept Dent, 155,Sec 2,Li Nong St, Taipei 112, Taiwan
2.Natl Yang Ming Univ, Inst Oral Biol, Taipei 112, Taiwan
3.Far Eastern Mem Hosp, Dept Surg, New Taipei 220, Taiwan
4.Cheng Hsin Gen Hosp, Dent Dept, Taipei 112, Taiwan
5.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China
6.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
7.Asia Univ, Dept Biomed Informat & Med Engn, Taichung 413, Taiwan
8.China Med Univ, Grad Inst Basic Med Sci, Taichung 404, Taiwan
9.China Med Univ Hosp, Dept Med Res, Taichung 407, Taiwan
10.Taipei Vet Gen Hosp, Dept Stomatol, Taipei 112, Taiwan
Recommended Citation
GB/T 7714
Sun, Ying-Sui,Huang, Chi-Ya,Chen, Chiang-Sang,et al. Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin[J]. SURFACE & COATINGS TECHNOLOGY,2018,350:918-924.
APA Sun, Ying-Sui.,Huang, Chi-Ya.,Chen, Chiang-Sang.,Chang, Jean-Heng.,Hou, Wen-Tao.,...&Huang, Her-Hsiung.(2018).Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin.SURFACE & COATINGS TECHNOLOGY,350,918-924.
MLA Sun, Ying-Sui,et al."Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin".SURFACE & COATINGS TECHNOLOGY 350(2018):918-924.
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