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Corrosion and biological performance of biodegradable magnesium alloys mediated by low copper addition and processing
Yan, Xudong1; Wan, Peng2; Tan, Lili1; Zhao, Mingchun3; Qin, Ling4; Yang, Ke1
Corresponding AuthorWan, Peng(wanpeng@dgut.edu.cn)
2018-12-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume93Pages:565-581
AbstractMg-Cu alloys were designed by introducing the well-known antibacterial property of copper into magnesium alloy to solve the infection problem especially under the neutralised environment in vitro. In this paper, the Mg-Cu alloys with further processing by solution and extrusion were studied to optimise the corrosion-related performance for their future application. It was shown that the differences in the property profile of Mg-Cu alloys are dependent on different compositions as well as on different microstructures that are obtained by the different processing routes. Galvanic corrosion can be significantly relieved by solution treatment and extrusion due to decrease and well distribution of cathodic Mg2Cu phases. Negligible cytotoxicity were observed with rBMSCs incubation. Antibacterial assays proved that the alloys reduced the viability of Staphylococcus aureus by high alkalinity and copper ions releasing, especially in comparison with pure magnesium. Finally, the as-solutionized Mg-0.1Cu alloy showed the optimal corrosion properties and promising antibacterial activity, which warranted its potentials as antibacterial biodegradable implant materials.
KeywordMagnesium alloy Copper Corrosion Processing Antibacterial
Funding OrganizationNational Natural Science Foundation of China ; National High Technology Research and Development Program of China (863 Program) ; Hong Kong Scholar Program ; CAS-Crouctier Founding Scheme for Joint Laboratories
DOI10.1016/j.msec.2018.08.013
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31500777] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[81501859] ; National High Technology Research and Development Program of China (863 Program)[2015AA033701] ; Hong Kong Scholar Program ; CAS-Crouctier Founding Scheme for Joint Laboratories[CAS14303]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000447569400054
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/130012
Collection中国科学院金属研究所
Corresponding AuthorWan, Peng
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China
3.Cent S Univ, Sch Mat Sci & Engn, Changsha 410083, Peoples R China
4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Yan, Xudong,Wan, Peng,Tan, Lili,et al. Corrosion and biological performance of biodegradable magnesium alloys mediated by low copper addition and processing[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2018,93:565-581.
APA Yan, Xudong,Wan, Peng,Tan, Lili,Zhao, Mingchun,Qin, Ling,&Yang, Ke.(2018).Corrosion and biological performance of biodegradable magnesium alloys mediated by low copper addition and processing.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,93,565-581.
MLA Yan, Xudong,et al."Corrosion and biological performance of biodegradable magnesium alloys mediated by low copper addition and processing".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 93(2018):565-581.
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