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Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property
Guo, F.1,2; Jiao, K.1,2; Bai, Y.1,2; Guo, J.3; Chen, Q.4; Yang, R.1,2; Zhang, X.1,2
Corresponding AuthorGuo, J.(guojing@dlpu.edu.cn) ; Zhang, X.(xingzhang@imr.ac.cn)
2019
Source PublicationJOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
Volume35Issue:1Pages:207-215
AbstractTranscatheter aortic heart valves (TAHVs) have been widely used for aortic valve replacements, with less trauma and lower clinical risk compared with traditional surgical heart valve replacements. In the present study, composites of poly(ethylene glycol) diacrylate (PEGDA) hydrogels and anisotropic high-shrinkage polyethylene terephthalate/polyamide6 (PET-PA6) fabric (PEGDA/PET-PA6) were fabricated as artificial heart valve leaflets. Dynamic mechanical analyses (DMA) indicated that PEGDA/PET-PA6 composites possessed anisotropic mechanical properties (i.e., storage moduli similar to 23.30 +/- 1.36 MPa parallel to the aligned fabric fibers and similar to 9.68 +/- 0.90 MPa perpendicular to the aligned fibers at 1 Hz) that were comparable to aortic valve leaflets. The PEGDA/PET-PA6 composites with smooth surfaces were highly hydrophilic (contact angle similar to 41.6 degrees +/- 3.8 degrees) and had low-fouling properties without platelet adhesion, suggesting a low risk of thrombogenicity when they interacted with blood. Furthermore, transcatheter aortic heart valves were fabricated using nitinol self-expanding frames and PEGDA/PET-PA6 composites as artificial leaflets, which presented excellent hemodynamic performance with a large orifice area (1.75 cm(2)) and low regurgitation (3.41%), thus meeting the requirements of ISO 5840-3 standard. Therefore, PEGDA/PET-PA6 composites had suitable mechanical properties, good biocompatibility, and low-fouling properties, indicating that they might be used for TAHVs in the future. (C) 2018 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
KeywordTranscatheter aortic heart valve Textile fabric Poly(ethylene glycol) diacrylate Anti-fouling
Funding OrganizationNational Natural Science Foundation of China ; Hundred-Talent Program from Chinese Academy of Sciences
DOI10.1016/j.jmst.2018.09.026
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31670981] ; National Natural Science Foundation of China[31300788] ; Hundred-Talent Program from Chinese Academy of Sciences
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000449263900028
PublisherJOURNAL MATER SCI TECHNOL
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/130210
Collection中国科学院金属研究所
Corresponding AuthorGuo, J.; Zhang, X.
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 239056, Anhui, Peoples R China
3.Dalian Polytech Univ, Sch Text & Mat Engn, Dalian 116034, Peoples R China
4.Lumenous Peiertech, Jiangyin 214437, Peoples R China
Recommended Citation
GB/T 7714
Guo, F.,Jiao, K.,Bai, Y.,et al. Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(1):207-215.
APA Guo, F..,Jiao, K..,Bai, Y..,Guo, J..,Chen, Q..,...&Zhang, X..(2019).Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(1),207-215.
MLA Guo, F.,et al."Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.1(2019):207-215.
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