Optimizing mechanical property and cytocompatibility of the biodegradable Mg-Zn-Y-Nd alloy by hot extrusion and heat treatment

doi:10.1016/j.jmst.2018.09.020

IMR OpenIR

	Optimizing mechanical property and cytocompatibility of the biodegradable Mg-Zn-Y-Nd alloy by hot extrusion and heat treatment
	Kang, Yiyuan 1,2; Du, Beining 1; Li, Yueming 1; Wang, Baojie 3; Sheng, Liyuan 1; Shao, Longquan 2; Zheng, Yufeng 1; Xi, Tingfei 1
通讯作者	Sheng, Liyuan(lysheng@yeah.net) ; Shao, Longquan(shaolongquan@smu.edu.cn)
	2019
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	35 期号:1 页码:6-18
摘要	The Mg-Zn-Y-Nd alloy is a new type of degradable material for biomedical application. In the present study, Mg-6Zn-1.2Y-0.8Nd alloy was fabricated, and then extrusion and heat treatment were conducted to optimize its mechanical properties and cytocompatibility. The microstructure observation, mechanical property, degradation behavior and cytocompatibility tests were conducted on the Mg-Zn-Y-Nd alloy with three different states: as-cast (alloy C), as-extruded (alloy E) and extruded + heat treated (alloy EH). The results show that alloy C consists of coarse grains and continuous secondary phases. The extrusion process has caused incomplete recrystallization, and results in a mixed grain structure of elongated grains and small equiaxed grains (alloy E). The heat treatment process has promoted the recrystallization and homogenized the grain structure (alloy EH). Both the strength and ductility of the alloy has been improved by extrusion, but the following heat treatment has decreased the strength and increased the ductility. The degradation behavior of the alloy C and E alloys does not show much difference, but improves slightly in alloy EH, because the heat treatment has homogenized the microstructure and released the residual stress in the alloy. The directly and indirectly cell viability tests indicate that alloy EH exhibits the best cytocompatibility, which should be ascribed to its relative uniform degradation and low ion releasing rate. In summary, the combination of hot extrusion and heat treatment could optimize the mechanical property and cytocompatibility of the Mg-Zn-Y-Nd alloy together, which is beneficial for the future application of the alloy. (C) 2018 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Mg-Zn-Y-Nd alloy Microstructure Mechanical property Biodegradable behavior Biocompatibility
资助者	National Key Research and Development Program of China ; Shenzhen Basic Research Project ; Shenzhen Technology Innovation Plan
DOI	10.1016/j.jmst.2018.09.020
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFC1102601] ; Shenzhen Basic Research Project[JCYJ2015052916222873] ; Shenzhen Basic Research Project[JCYJ20160407090231002] ; Shenzhen Basic Research Project[JCYJ20150625155931806] ; Shenzhen Basic Research Project[JCYJ20160427100211076] ; Shenzhen Basic Research Project[JCYJ20170306141749970] ; Shenzhen Technology Innovation Plan[CXZZ20140731091722497] ; Shenzhen Technology Innovation Plan[CXZZ20140419114548507]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000449263900002
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：63[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/130436
专题	中国科学院金属研究所
通讯作者	Sheng, Liyuan; Shao, Longquan
作者单位	1.Peking Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Kang, Yiyuan,Du, Beining,Li, Yueming,et al. Optimizing mechanical property and cytocompatibility of the biodegradable Mg-Zn-Y-Nd alloy by hot extrusion and heat treatment[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(1):6-18.
APA	Kang, Yiyuan.,Du, Beining.,Li, Yueming.,Wang, Baojie.,Sheng, Liyuan.,...&Xi, Tingfei.(2019).Optimizing mechanical property and cytocompatibility of the biodegradable Mg-Zn-Y-Nd alloy by hot extrusion and heat treatment.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(1),6-18.
MLA	Kang, Yiyuan,et al."Optimizing mechanical property and cytocompatibility of the biodegradable Mg-Zn-Y-Nd alloy by hot extrusion and heat treatment".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.1(2019):6-18.