Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings

doi:10.1016/j.msec.2019.02.067

IMR OpenIR

	Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings
	Wang, W.1,4; Nune, K. C.2; Tan, L.1; Zhang, N.3; Dong, J.1; Yan, J.3; Misra, R. D. K.2; Yang, K.1
通讯作者	Tan, L.(lltan@imr.ac.cn) ; Misra, R. D. K.(dmisra2@utep.edu) ; Yang, K.(kyang@imr.ac.cn)
	2019-07-01
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
卷号	100 页码:297-307
摘要	Segmental defects are formidable challenges for orthopedic surgeons that are caused by large osseous defects such as open injury, comminuted fracture as well as other severe traumas and infection. Current treatment options have practical and clinical shortcomings, calling for innovative bone graft materials. This study is related to hollow tubular magnesium-strontium (Mg-Sr) alloy scaffolds with autologous morselized bone filled inside and three different coatings were individually applied on Mg-Sr scaffolds, respectively, to study the effects of degradation and bioactivity of the grafts on new bone growth. The optimal coating method was screened using immersion tests, cell proliferation and adhesion, alkaline phosphatase (ALP) assay in vitro, and 4 weeks' implantation in a critical-size segmental defect in vivo. More new bone formation was observed by radiographic tests and histology along the ulna defects, when magnesium scaffold grafts were implanted. Meanwhile, depression occurred for blank control group with only autologous morselized bone filled, because of rapid absorption rate of morselized bone during initial implantation. Therefore, biodegradable Mg-Sr alloy grafts showed their potential application in treating the critical-size segmental defects. As for different coating methods, CaP chemically deposited (CaP) coated sample showed least H-2 evolution in vivo, demonstrating highest corrosion resistance and relative stable interfaces, however, the least beneficial ion release meanwhile. Micro-arc oxidation coating (MAO) degraded faster comparing with CaP, while with the main composition of MgO. They both indicate insufficient bioactivity in bone formation. The results suggest superior combination of bioactive surface, beneficial ions release and appropriate corrosion rate of Strontium phosphate conversion (SrP) coating, indicating superior comprehensive oeteoconductive and osteoinductive properties of coatings on hollow tubular Mg-Sr alloy scaffold.
关键词	Biodegradable magnesium alloy Coating Scaffold Segmental defect Bone regeneration
资助者	Key program of China on biomedical materials research and tissue and organ replacement ; National Natural Science Foundation of China ; Institute of Metal Research, Chinese Academy of Sciences ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
DOI	10.1016/j.msec.2019.02.067
收录类别	SCI
语种	英语
资助项目	Key program of China on biomedical materials research and tissue and organ replacement[2016YFC1101804] ; Key program of China on biomedical materials research and tissue and organ replacement[2016YFC1100604] ; National Natural Science Foundation of China[31500777] ; Institute of Metal Research, Chinese Academy of Sciences[2015-ZD01] ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000466059700029
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：42[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/133315
专题	中国科学院金属研究所
通讯作者	Tan, L.; Misra, R. D. K.; Yang, K.
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Texas El Paso, Dept Met Mat & Biomed Engn, El Paso, TX 79968 USA 3.Harbin Med Univ, Affiliated Hosp 2, Dept Orthoped Surg, Harbin 150081, Heilongjiang, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, W.,Nune, K. C.,Tan, L.,et al. Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,100:297-307.
APA	Wang, W..,Nune, K. C..,Tan, L..,Zhang, N..,Dong, J..,...&Yang, K..(2019).Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,100,297-307.
MLA	Wang, W.,et al."Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 100(2019):297-307.