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Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment
Zhao, Jinlong1,2; Zhai, Zhaofeng1,2; Sun, Da3,4; Yang, Chunguang1; Zhang, Xinrui1,2; Huang, Nan1; Jiang, Xin1; Yang, Ke1
Corresponding AuthorYang, Chunguang(cgyang@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
2019-07-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume100Pages:396-410
AbstractStainless steel (SS) has been widely applied as one of the most efficient implant metal materials, although corrosion and infection in body environment are still challenging. Herein, an antibacterial passivation method was employed to enhance the antibacterial performance and corrosion resistance of the medical 316L SS. The result proved that the antibacterial-passivated 316L SS exhibited stable antibacterial activity and effectively inhibited the formation of bacterial biofilm. Electrochemical measurements combined with X-ray photoelectron spectroscopy technique were used to study the corrosion resistance and semiconductor behavior of passivated 316L SS immersed in simulated physiological environment. The results indicated that the 316L SS after anti-bacterial passivation treatment for 1 h, soaking in the medium for 10 days, showed satisfactory corrosion resistance attributing to proper Cu deposition in the passive film. The anodic stripping voltammetry measurement further confirmed that the Cu-bearing passive film could continuously release Cu ions into medium. The zebrafish test demonstrated an excellent in vivo biocompatibility for the 316L SS with antibacterial passivation for 0.5 and 1 h, respectively. In addition, changes of surface roughness, contact angle and chemical composition after antibacterial passivation played an important role in explaining the antibacterial mechanism, which could be clearly divided into contact killing and ionic release killing. Hence, the antibacterial passivation treatment was preliminarily proved as a potential way for enhancing the persistent antibacterial activity and corrosion resistance of 316L SS.
KeywordStainless steel Passive film Antibacterial passivation treatment Cu ion Antibacterial activity
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; State Key Program of National Natural Science of China ; Natural Science Foundation of Zhejiang Province ; Shenzhen-Hong Kong Technology Cooperation Funding Scheme ; Shenzhen Science and Technology Research Funding
DOI10.1016/j.msec.2019.03.021
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFB0300205] ; National Natural Science Foundation of China[51501188] ; National Natural Science Foundation of China[51771199] ; State Key Program of National Natural Science of China[51631009] ; Natural Science Foundation of Zhejiang Province[LQ19E010004] ; Shenzhen-Hong Kong Technology Cooperation Funding Scheme[SGLH20150213143207910] ; Shenzhen Science and Technology Research Funding[JCYJ 20160608153641020]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000466059700039
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/133350
Collection中国科学院金属研究所
Corresponding AuthorYang, Chunguang; Yang, Ke
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China
3.Wenzhou Univ, Inst Life Sci, Wenzhou 325000, Peoples R China
4.Wenzhou Med Univ, Sch Nursing, Chinese Amer Res Inst Diabet Complicat, Sch Pharmaceut Sci, Wenzhou 325000, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Jinlong,Zhai, Zhaofeng,Sun, Da,et al. Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,100:396-410.
APA Zhao, Jinlong.,Zhai, Zhaofeng.,Sun, Da.,Yang, Chunguang.,Zhang, Xinrui.,...&Yang, Ke.(2019).Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,100,396-410.
MLA Zhao, Jinlong,et al."Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 100(2019):396-410.
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