Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response

doi:10.1080/10667857.2019.1574956

IMR OpenIR

	Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response
	Patil, Sachin S.1; Misra, R. D. K.1; Gao, M.2; Ma, Z.2; Tan, L.2; Yang, K.2
通讯作者	Misra, R. D. K.(dmisra2@utep.edu)
	2019-06-07
发表期刊	MATERIALS TECHNOLOGY
ISSN	1066-7857
卷号	34 期号:7 页码:394-402
摘要	Pure magnesium implants have a problem of faster degradation which leads to the collapse of the implant before the recovery of physiological organ. A new magnesium alloy viz Mg-2Zn-0.5Nd (ZN20) is designed using a well-known alloying method to decrease the degradation rate of pure magnesium metal and its implants so as to match the tissue recovery rate. MTT assay of the ZN20 alloy via a direct contact method for 2, 4 and 6 days using MC3T3-E1 cells showed cytotoxicity. Whereas, the MTT assay results of this alloy via ion-extract method showed non-cytotoxic behaviour. The degradation rate of ZN20 alloy in SBF was similar to 2.5% in 16 days which is comparable to the rate of regeneration and recovery of physiological tissue. The pH of the outer solution after degradation of ZN20 alloy for 3 days was around 9.31 +/- 0.05 which was higher than the initial pH of SBF used (pH 7.4). The reason for the cytotoxic behaviour of this alloy could be the increase in pH of immersion solution with the degradation of the alloy. Interestingly, the scanning electron microscope images followed by EDX spectrum of ZN20 alloy showed deposition of white crystalline mineralisation product (apatite) after 3, 7, 11 and 16 days of incubation in SBF at 37 degrees C. The FT-IR spectrum and X-ray chromatogram of the white substance confirmed the deposition of apatite (calcium phosphate) on their surfaces. These results concluded the bioactivity of ZN20 alloy and thus could be used as an implant material for regeneration of bones/tissues.
关键词	Magnesium alloy bioactivity calcium phosphate apatite metal implants
DOI	10.1080/10667857.2019.1574956
收录类别	SCI
语种	英语
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000467883400004
出版者	TAYLOR & FRANCIS LTD
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/133392
专题	中国科学院金属研究所
通讯作者	Misra, R. D. K.
作者单位	1.Univ Texas El Paso, Dept Met Mat & Biomed Engn, 500 W Univ Ave, El Paso, TX 79968 USA 2.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Patil, Sachin S.,Misra, R. D. K.,Gao, M.,et al. Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response[J]. MATERIALS TECHNOLOGY,2019,34(7):394-402.
APA	Patil, Sachin S.,Misra, R. D. K.,Gao, M.,Ma, Z.,Tan, L.,&Yang, K..(2019).Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response.MATERIALS TECHNOLOGY,34(7),394-402.
MLA	Patil, Sachin S.,et al."Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response".MATERIALS TECHNOLOGY 34.7(2019):394-402.