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In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy
Liu, Rui1,2; Ma, Zheng2; Kolawole, Sharafadeen Kunle2; Zeng, Lilan3; Zhao, Ying3; Ren, Ling2; Yang, Ke2
Corresponding AuthorZhao, Ying(ying.zhao@siat.ac.cn) ; Ren, Ling(lren@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
2019-07-01
Source PublicationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN0957-4530
Volume30Issue:7Pages:10
AbstractTitanium implants easily suffer bacteria-related infections in clinic due to their inherent lack of self-protection ability. Therefore, a novel Ti-Cu alloy with good antibacterial activity has been developed as a new kind of implant material. This study focuses on a systematic evaluation of both cytocompatibility and osteogenesis activity of the Ti-Cu alloy in vitro. It was revealed that an addition of 5% Cu into pure Ti would not cause any negative effect on osteoblasts adhesion, proliferation and apoptosis cultured with Ti-Cu alloy. In addition, Ti-Cu alloy could significantly promote the osteogenic differentiation of MG 63 cells by upregulating the osteogenesis-related gene expressions including alkaline phosphatase (ALP), Collagen I (Colla I), osteopontin (OPN) and osteocalcin (OCN). These promising results suggest that the Ti-Cu alloy has great potential to be used as a multi-functional titanium implant for clinical applications. [GRAPHICS]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation ; Institute of Metal Research, Chinese Academy of Sciences ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences ; Shenzhen Science and Technology Research Funding
DOI10.1007/s10856-019-6277-z
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation[51631009] ; National Natural Science Foundation[51811530320] ; National Natural Science Foundation[81572113] ; Institute of Metal Research, Chinese Academy of Sciences[2017-ZD01] ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences[174321KYSB2018000] ; Shenzhen Science and Technology Research Funding[JCYJ20160608153641020]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000472211800003
PublisherSPRINGER
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/134044
Collection中国科学院金属研究所
Corresponding AuthorZhao, Ying; Ren, Ling; Yang, Ke
Affiliation1.Northeastern Univ, 3-11 Wenhua Rd, Shenyang 110819, Liaoning, Peoples R China
2.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Recommended Citation
GB/T 7714
Liu, Rui,Ma, Zheng,Kolawole, Sharafadeen Kunle,et al. In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2019,30(7):10.
APA Liu, Rui.,Ma, Zheng.,Kolawole, Sharafadeen Kunle.,Zeng, Lilan.,Zhao, Ying.,...&Yang, Ke.(2019).In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,30(7),10.
MLA Liu, Rui,et al."In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 30.7(2019):10.
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