Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model

doi:10.1039/c8ra03157f

IMR OpenIR

	Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model
	Ding, Yurun 1; Du, Zhe 2; Zhu, Zhonglin 3; Yu, Xiaoming 4; Wang, You 1
通讯作者	Wang, You(drwangyou@163.com)
	2018
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	8 期号:44 页码:25127-25132
摘要	Biodegradable magnesium (Mg)-copper (Cu) coatings are promising in orthopedic implants to enhance osteogenesis. The present study aimed to compare the osteogenic effect of Mg-Cu coating and non-coating implants using a rabbit model. Mg/Mg-Cu coating of porous Ti6Al4V alloys was performed by the arc ion plating method. Five porous implants (smooth, porous, Mg coated, Mg-0.1Cu coated, and Mg-0.7Cu coated) were implanted into the distal femurs of the rabbits. The rabbits were sacrificed after one and two months, respectively, and the distal femurs with the implants were analyzed via micro-computed tomography (CT), double fluorescent labeling, and hard tissue biopsy to evaluate their osteogenic effect. During the two months of observation, the Mg/Mg-Cu coatings exhibited no advantages when compared with the bare porous structures in terms of bone integration; however, the porous structures were more conducive for bone ingrowth than the smooth implants. The osteogenic application of Mg-Cu coated orthopedic implants is worth further investigation. Furthermore, due to its long-term antibacterial ability, the biodegradable Mg-Cu coatings are promising in orthopedic applications.
资助者	National Key R&D Program of China
DOI	10.1039/c8ra03157f
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2016YFC1101802] ; National Key R&D Program of China[2016YFC1101804]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000438939300050
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/135870
专题	中国科学院金属研究所
通讯作者	Wang, You
作者单位	1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Bone & Joint Surg, 145 Middle Shandong Rd, Shanghai 200001, Peoples R China 2.Peking Univ, Peoples Hosp, Trauma & Emergency Ctr, Beijing, Peoples R China 3.Jiangsu OKANI Med Technol Co Ltd, Suzhou, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Ding, Yurun,Du, Zhe,Zhu, Zhonglin,et al. Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model[J]. RSC ADVANCES,2018,8(44):25127-25132.
APA	Ding, Yurun,Du, Zhe,Zhu, Zhonglin,Yu, Xiaoming,&Wang, You.(2018).Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model.RSC ADVANCES,8(44),25127-25132.
MLA	Ding, Yurun,et al."Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model".RSC ADVANCES 8.44(2018):25127-25132.