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Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model
Ding, Yurun1; Du, Zhe2; Zhu, Zhonglin3; Yu, Xiaoming4; Wang, You1
Corresponding AuthorWang, You(drwangyou@163.com)
2018
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume8Issue:44Pages:25127-25132
AbstractBiodegradable magnesium (Mg)-copper (Cu) coatings are promising in orthopedic implants to enhance osteogenesis. The present study aimed to compare the osteogenic effect of Mg-Cu coating and non-coating implants using a rabbit model. Mg/Mg-Cu coating of porous Ti6Al4V alloys was performed by the arc ion plating method. Five porous implants (smooth, porous, Mg coated, Mg-0.1Cu coated, and Mg-0.7Cu coated) were implanted into the distal femurs of the rabbits. The rabbits were sacrificed after one and two months, respectively, and the distal femurs with the implants were analyzed via micro-computed tomography (CT), double fluorescent labeling, and hard tissue biopsy to evaluate their osteogenic effect. During the two months of observation, the Mg/Mg-Cu coatings exhibited no advantages when compared with the bare porous structures in terms of bone integration; however, the porous structures were more conducive for bone ingrowth than the smooth implants. The osteogenic application of Mg-Cu coated orthopedic implants is worth further investigation. Furthermore, due to its long-term antibacterial ability, the biodegradable Mg-Cu coatings are promising in orthopedic applications.
Funding OrganizationNational Key R&D Program of China
DOI10.1039/c8ra03157f
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2016YFC1101802] ; National Key R&D Program of China[2016YFC1101804]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000438939300050
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/135870
Collection中国科学院金属研究所
Corresponding AuthorWang, You
Affiliation1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Bone & Joint Surg, 145 Middle Shandong Rd, Shanghai 200001, Peoples R China
2.Peking Univ, Peoples Hosp, Trauma & Emergency Ctr, Beijing, Peoples R China
3.Jiangsu OKANI Med Technol Co Ltd, Suzhou, Peoples R China
4.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Ding, Yurun,Du, Zhe,Zhu, Zhonglin,et al. Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model[J]. RSC ADVANCES,2018,8(44):25127-25132.
APA Ding, Yurun,Du, Zhe,Zhu, Zhonglin,Yu, Xiaoming,&Wang, You.(2018).Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model.RSC ADVANCES,8(44),25127-25132.
MLA Ding, Yurun,et al."Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model".RSC ADVANCES 8.44(2018):25127-25132.
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