Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment

doi:10.1002/admi.201901632

IMR OpenIR

	Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment
	Guo, Yu 1,2; Ren, Ling 3; Xie, Kai 1,2; Wang, Lei 1,2; Yu, Baohai 3; Jiang, Wenbo 2; Zhao, Yanhui 3; Hao, Yongqiang 1,2
通讯作者	Wang, Lei(hyq_9hospital@hotmail.com) ; Zhao, Yanhui(yhzhao@imr.ac.cn) ; Hao, Yongqiang(118062@sh9hospital.org)
	2020-01-31
发表期刊	ADVANCED MATERIALS INTERFACES
ISSN	2196-7350
卷号	7 期号:6 页码:13
摘要	Ti6Al4V scaffolds have high strength and corrosion resistance. 3D printing technology can optimize the pore structure of Ti6Al4V scaffolds, promoting bone tissue growth into the scaffolds to form firm osseointegrations. However, Ti6Al4V lacks biological activity. This defect can be overcome through surface modifications. Arc ion plating is employed to prepare titanium copper/titanium copper nitride (TiCu/Ti-Cu-N) multilayer coating, which is applied to 3D-printed porous Ti6Al4V scaffolds by selective laser melting and bearing 300-400 mu m pores. In addition to the excellent biological activity of copper, TiN shows superior corrosion resistance. The scaffold properties, osteogenesis, and osteointegration are evaluated in vitro and in vivo. Results show that human bone mesenchymal stem cells (hBMSCs) proliferate and adhere more effectively on coated scaffolds than on uncoated scaffolds. Further, the coating has a significant role in recruiting hBMSCs, and upregulation of the SDF-1 alpha/CXCR4 axis, p38 expression, and extracellular signal-related kinase (Erk) and Akt signaling pathway. The in vitro results are further confirmed by an animal experiment in the New Zealand white rabbit femur tibia defect. Overall, the TiCu/Ti-Cu-N-coated 3D-printed Ti6Al4V scaffold shows excellent biocompatibility and bioactivity in promoting bone repair. The underlying mechanism may involve recruiting BMSCs and promoting their osteogenic differentiation.
关键词	BMSC recruitment nitride-titanium-copper orthopedic implant osteogenesis selective laser melting
资助者	National Key R&D Program of China
DOI	10.1002/admi.201901632
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2016YFC1100600] ; National Key R&D Program of China[2016YFC1100604]
WOS研究方向	Chemistry ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Materials Science, Multidisciplinary
WOS记录号	WOS:000510253900001
出版者	WILEY
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/137201
专题	中国科学院金属研究所
通讯作者	Wang, Lei; Zhao, Yanhui; Hao, Yongqiang
作者单位	1.Shanghai Jiao Tong Univ, A Shanghai Key Lab Orthopaed Implants, Dept Orthopaed Surg, Shanghai Peoples Hosp 9,Sch Med, Shanghai 200011, Peoples R China 2.Shanghai Jiao Tong Univ, Clin & Translat Res Ctr 3D Printing Technol, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Special Mat & Device Res Dept, Shenyang 110000, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yu,Ren, Ling,Xie, Kai,et al. Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment[J]. ADVANCED MATERIALS INTERFACES,2020,7(6):13.
APA	Guo, Yu.,Ren, Ling.,Xie, Kai.,Wang, Lei.,Yu, Baohai.,...&Hao, Yongqiang.(2020).Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment.ADVANCED MATERIALS INTERFACES,7(6),13.
MLA	Guo, Yu,et al."Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment".ADVANCED MATERIALS INTERFACES 7.6(2020):13.