Contact Killing of Cu-Bearing Stainless Steel Based on Charge Transfer Caused by the Microdomain Potential Difference

doi:10.1021/acsami.9b19596

IMR OpenIR

	Contact Killing of Cu-Bearing Stainless Steel Based on Charge Transfer Caused by the Microdomain Potential Difference
	Zhang, Xinrui 1,2; Yang, Chunguang 2; Yang, Ke 2
通讯作者	Yang, Chunguang(cgyang@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
	2020-01-08
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	12 期号:1 页码:361-372
摘要	The addition of copper makes the Cu-bearing stainless steel (SS) possess excellent antibacterial properties. However, the antibacterial mechanism of the Cu-bearing SS is still not accurately understood and recognized. On the one hand, the concentration of released antibacterial Cu ions from its surface is insufficient to generate such an effect. On the other hand, due to the limited Cu content, the area of copper toxicity that can be contacted with bacteria is also much less than that of pure Cu. Therefore, the purpose of this study was to explore the way of bacterial inactivation caused by Cu-bearing SS from the view of the charge transfer. The results showed that the continuous and effective contact between bacteria and Cu-bearing SS is the key to induce the bacteria-killing effect so that the cathode electrons generated by the potential difference of the material microdomain can cause the proton depletion in the bacterial cells, thereby disturbing the respiratory chain and energy generation of the bacterial cells. The proton depletion reaction also catalyzed the conversion of Cu(II) into Cu(I). Cu(I) not only destroys the iron-sulfur protein but also undergoes the redox reaction with Cu(II) to produce reactive oxygen species, causing oxidative damage to cells, eventually accelerating the bacterial death.
关键词	Cu-bearing stainless steel contact killing charge transfer surface potential Cu(I) Cu(II)
资助者	National Natural Science Foundation of China ; National Key Research and Development Program of China ; State Key Program of National Natural Science Foundation of China ; Shenzhen Science and Technology Research Program
DOI	10.1021/acsami.9b19596
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51501188] ; National Natural Science Foundation of China[51771199] ; National Key Research and Development Program of China[2016YFB0300205] ; State Key Program of National Natural Science Foundation of China[51631009] ; Shenzhen Science and Technology Research Program[JCYJ20160608153641020]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000507146100031
出版者	AMER CHEMICAL SOC
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/137223
专题	中国科学院金属研究所
通讯作者	Yang, Chunguang; Yang, Ke
作者单位	1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xinrui,Yang, Chunguang,Yang, Ke. Contact Killing of Cu-Bearing Stainless Steel Based on Charge Transfer Caused by the Microdomain Potential Difference[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(1):361-372.
APA	Zhang, Xinrui,Yang, Chunguang,&Yang, Ke.(2020).Contact Killing of Cu-Bearing Stainless Steel Based on Charge Transfer Caused by the Microdomain Potential Difference.ACS APPLIED MATERIALS & INTERFACES,12(1),361-372.
MLA	Zhang, Xinrui,et al."Contact Killing of Cu-Bearing Stainless Steel Based on Charge Transfer Caused by the Microdomain Potential Difference".ACS APPLIED MATERIALS & INTERFACES 12.1(2020):361-372.