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Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits
Liu, Xiaohan1; Hu, Ying2; Wu, Lin1; Li, Shujun3
Corresponding AuthorWu, Lin(wulin13@163.com)
2020-02-01
Source PublicationANNALS OF TRANSLATIONAL MEDICINE
ISSN2305-5839
Volume8Issue:4Pages:9
AbstractBackground: This study was to evaluate the effects of low-intensity collimated pulse ultrasound (LICU) and low-intensity focused-pulse ultrasound (LIFU) stimulation on the osteogenesis in the porous silicon carbide (SiC) scaffold implanted in the rabbit mandible. Methods: Rabbits were randomly divided into LIFU group, LICU group and control group (without ultrasound treatment). The intensities of LICU and LIFU were 30 and 300 mW/cm(2), respectively. The subcutaneous and subperiosteal temperatures were measured continuously during the 20-min ultrasound treatment. Then, the porous SiC scaffolds were implanted into the mandible, followed by LICU or LIFU once daily, and the quantity and structure of bone were assessed by methylene blue-acid fuchsin staining and micro-CT at 3, 6 and 9 weeks after implantation. Results: The changes in the subcutaneous and subperiosteal temperatures during LICU and LIFU were less than 1 degrees C. The bone mass increased and the structure of bone tissues became more mature over time. The bone mass and mean pore occupancy fraction (POF) in the LIFU group were significantly greater than in the LICU group at three time points (P<0.05). Bone ingrowth in different directions was observed, and the new bone formation in the mesial, distal, top, and lingual sides of the implants in the LIFU group was greater than in the LICU group and control group (P<0.05). Conclusions: LIEU and LICU may effectively promote bone formation in the mandible scaffold, and LIFU significantly accelerates bone formation in both buccal side and lingual side of the scaffold.
KeywordOsteogenesis low-intensity collimated pulse ultrasound (LICU) low-intensity focused-pulse ultrasound (LIFU) porous SiC scaffold
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; Natural Science Foundation of the Higher Education Institutions of Liaoning Province
DOI10.21037/atm.2019.12.89
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[81870811] ; Natural Science Foundation of the Higher Education Institutions of Liaoning Province[LQNK201722]
WOS Research AreaOncology ; Research & Experimental Medicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS IDWOS:000518410000050
PublisherAME PUBL CO
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/137561
Collection中国科学院金属研究所
Corresponding AuthorWu, Lin
Affiliation1.China Med Univ, Sch & Hosp Stomatol, Dept Prosthodont, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China
2.Dalian Stomatol Hosp, Dept Pediat Dent, Dalian 116021, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xiaohan,Hu, Ying,Wu, Lin,et al. Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits[J]. ANNALS OF TRANSLATIONAL MEDICINE,2020,8(4):9.
APA Liu, Xiaohan,Hu, Ying,Wu, Lin,&Li, Shujun.(2020).Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits.ANNALS OF TRANSLATIONAL MEDICINE,8(4),9.
MLA Liu, Xiaohan,et al."Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits".ANNALS OF TRANSLATIONAL MEDICINE 8.4(2020):9.
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