Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits

doi:10.21037/atm.2019.12.89

IMR OpenIR

	Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits
	Liu, Xiaohan 1; Hu, Ying 2; Wu, Lin 1; Li, Shujun 3
通讯作者	Wu, Lin(wulin13@163.com)
	2020-02-01
发表期刊	ANNALS OF TRANSLATIONAL MEDICINE
ISSN	2305-5839
卷号	8 期号:4 页码:9
摘要	Background: This study was to evaluate the effects of low-intensity collimated pulse ultrasound (LICU) and low-intensity focused-pulse ultrasound (LIFU) stimulation on the osteogenesis in the porous silicon carbide (SiC) scaffold implanted in the rabbit mandible. Methods: Rabbits were randomly divided into LIFU group, LICU group and control group (without ultrasound treatment). The intensities of LICU and LIFU were 30 and 300 mW/cm(2), respectively. The subcutaneous and subperiosteal temperatures were measured continuously during the 20-min ultrasound treatment. Then, the porous SiC scaffolds were implanted into the mandible, followed by LICU or LIFU once daily, and the quantity and structure of bone were assessed by methylene blue-acid fuchsin staining and micro-CT at 3, 6 and 9 weeks after implantation. Results: The changes in the subcutaneous and subperiosteal temperatures during LICU and LIFU were less than 1 degrees C. The bone mass increased and the structure of bone tissues became more mature over time. The bone mass and mean pore occupancy fraction (POF) in the LIFU group were significantly greater than in the LICU group at three time points (P<0.05). Bone ingrowth in different directions was observed, and the new bone formation in the mesial, distal, top, and lingual sides of the implants in the LIFU group was greater than in the LICU group and control group (P<0.05). Conclusions: LIEU and LICU may effectively promote bone formation in the mandible scaffold, and LIFU significantly accelerates bone formation in both buccal side and lingual side of the scaffold.
关键词	Osteogenesis low-intensity collimated pulse ultrasound (LICU) low-intensity focused-pulse ultrasound (LIFU) porous SiC scaffold
资助者	National Natural Science Foundation of China (NSFC) ; Natural Science Foundation of the Higher Education Institutions of Liaoning Province
DOI	10.21037/atm.2019.12.89
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China (NSFC)[81870811] ; Natural Science Foundation of the Higher Education Institutions of Liaoning Province[LQNK201722]
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS类目	Oncology ; Medicine, Research & Experimental
WOS记录号	WOS:000518410000050
出版者	AME PUBL CO
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/137561
专题	中国科学院金属研究所
通讯作者	Wu, Lin
作者单位	1.China Med Univ, Sch & Hosp Stomatol, Dept Prosthodont, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China 2.Dalian Stomatol Hosp, Dept Pediat Dent, Dalian 116021, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiaohan,Hu, Ying,Wu, Lin,et al. Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits[J]. ANNALS OF TRANSLATIONAL MEDICINE,2020,8(4):9.
APA	Liu, Xiaohan,Hu, Ying,Wu, Lin,&Li, Shujun.(2020).Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits.ANNALS OF TRANSLATIONAL MEDICINE,8(4),9.
MLA	Liu, Xiaohan,et al."Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits".ANNALS OF TRANSLATIONAL MEDICINE 8.4(2020):9.