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Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating
Ullah, Ihsan1,2; Siddiqui, Muhammad Ali1,2; Liu, Hui1,2; Kolawole, Sharafadeen Kunle1,2; Zhang, Ji1; Zhang, Shuyuan1; Ren, Ling1; Yang, Ke1
Corresponding AuthorRen, Ling(lren@imr.ac.cn)
2020-03-01
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume6Issue:3Pages:1355-1366
AbstractImplant-related infections are a major concern in total joint prostheses, occurring up to 3% in operations. In this work, 5% Zn2+ was added in I-TA to offset bacterial activity and 5% Sr2+ was also incorporated as a binary dopant to reduce the cytotoxic effect of Zn2+. The nanosized HA powder was synthesized by the hydrothermal method and then heat-treated at 600 degrees C for 4 h. The heat-treated powder was plasma-sprayed on a titanium alloy Ti-6Al-4V substrate. The addition of the dopant did not significantly influence the physical and mechanical properties of the coating. However, the cytocompatibility, antimicrobial, and contact-angle properties statistically enhanced. Moreover, the (Sr,Zn)-HA coating was post-heat treated at 500 and 600 degrees C for 3 h. X-ray diffraction confirmed that after heat treatment phase purity and crystallinity increased and residual stress decreased. Mechanical stability was evaluated by adhesive bond strength, and the results showed that after heat-treatment bonding strength increased from 26.81 +/- 2.93 to 29.84 +/- 3.62 and 34.66 +/- 2.57 MPa, at 500 and 600 degrees C, respectively. Similar to the mechanical property, antibacterial activities and biological functions are also significantly improved. More interestingly, it was also observed that the Zn2+ ions released from the coating depend on Ca2+, P, and Sr2+ ions while Ca2+, P, and Sr2+ ions relied on heat treatment temperatures. However, (Sr,Zn)-HA coating at 600 degrees C demonstrates cytotoxic effects on MC3T3-E1 cells, characterized by poor cellular morphology on the coating surface and ultimately, cell death. The doping of Sr2+ with Zn2+, therefore, can offset the cytotoxic effects and enhanced biological performance. All of the outcomes of this study signify that (Sr,Zn)-HA coating heat-treated at 500 degrees C showed not only excellent mechanical and biological performance but also enhanced the antibacterial properties.
KeywordHA coating plasma spray heat treatment antibacterial properties biocompatibility
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation ; Youth Innovation Promotion Association, CAS ; Promoting Liaoning Province Talents Program-Top Young Talents
DOI10.1021/acsbiomaterials.9b01396
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation[51631009] ; Youth Innovation Promotion Association, CAS[2014168] ; Promoting Liaoning Province Talents Program-Top Young Talents[XLYC1807069]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000519150300005
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/137834
Collection中国科学院金属研究所
Corresponding AuthorRen, Ling
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
Recommended Citation
GB/T 7714
Ullah, Ihsan,Siddiqui, Muhammad Ali,Liu, Hui,et al. Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(3):1355-1366.
APA Ullah, Ihsan.,Siddiqui, Muhammad Ali.,Liu, Hui.,Kolawole, Sharafadeen Kunle.,Zhang, Ji.,...&Yang, Ke.(2020).Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(3),1355-1366.
MLA Ullah, Ihsan,et al."Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.3(2020):1355-1366.
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