Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys

doi:10.1016/j.jmst.2020.02.017

IMR OpenIR

	Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys
	Jin, Shi 1,2; Zhang, Dan 1,2; Lu, Xiaopeng 4; Zhang, Yang 1,2; Tan, Lili 3; Liu, Ying 5; Wang, Qiang 1,2
通讯作者	Zhang, Yang(kp3666@126.com) ; Wang, Qiang(mfqwang@163.com)
	2020-06-15
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	47 页码:190-201
摘要	Biodegradable magnesium alloys have been turned out to be a promising candidate for orthopedic applications. In this study, the mechanical properties, degradation behavior and cytocompatibility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were studied in comparison with pure Mg. Mechanical tests showed that the strength and ductility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were excellent. The corrosion resistance analyzed by electrochemical test and immersion test in alpha modified eagle (alpha-MEM) medium with 10% fetal bovine serum (FBS) revealed the degradation of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were faster than pure Mg at an early stage but slowed down after long time immersion. The metal ion concentrations were consistent with the corrosion rate. Mg-Zn-Zr-Nd alloy shows better mechanical properties than pure Mg and better corrosion resistance than Mg-Zn-Zr-Y alloy. The direct and indirect in vitro tests with MC3T3-E1 cells demonstrate that Mg-Zn-Zr-Nd shows the best cytocompatibility and osteogenesis. The results suggest that Mg-Zn-Zr-Nd alloy shows an ideal combination of mechanical, corrosive and biological properties. In summary, these results implying the Mg-Zn-Zr-Nd alloy has great potential to benefit the future development of orthopedic applications. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Magnesium Mg-Zn-Zr-Nd alloy Mg-Zn-Zr-Y alloy Biodegradable implant Biocompatibility
资助者	National NaturalScience Foundation of China ; Young Elite Scientists Sponsorship Program by China Association for Science andTechnology ; Shenyang Key R&D and Technology Transfer Program ; Key Programof China on Biomedical Materials Research and Tissue and OrganReplacement
DOI	10.1016/j.jmst.2020.02.017
收录类别	SCI
语种	英语
资助项目	National NaturalScience Foundation of China[U1737102] ; Young Elite Scientists Sponsorship Program by China Association for Science andTechnology[2017QNRC001] ; Shenyang Key R&D and Technology Transfer Program[Z18-0-027] ; Key Programof China on Biomedical Materials Research and Tissue and OrganReplacement[2016YFC1101804] ; Key Programof China on Biomedical Materials Research and Tissue and OrganReplacement[2016YFC1100604]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000526956900020
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：80[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/138413
专题	中国科学院金属研究所
通讯作者	Zhang, Yang; Wang, Qiang
作者单位	1.China Med Univ, Sch & Hosp Stomatol, Shenyang 110001, Peoples R China 2.Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Northeastern Univ, Shenyang Natl Lab Mat Sci, Shenyang 110819, Peoples R China 5.Jiamusi Univ, Sch Stomatol, Jiamusi 154007, Peoples R China
推荐引用方式 GB/T 7714	Jin, Shi,Zhang, Dan,Lu, Xiaopeng,et al. Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2020,47:190-201.
APA	Jin, Shi.,Zhang, Dan.,Lu, Xiaopeng.,Zhang, Yang.,Tan, Lili.,...&Wang, Qiang.(2020).Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,47,190-201.
MLA	Jin, Shi,et al."Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 47(2020):190-201.