IMR OpenIR
Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application
Ullah, Ihsan1,2; Siddiqui, Muhammad Ali1,2,3; Kolawole, Sharafadeen Kunle1,2; Liu, Hui1,2; Zhang, Ji1; Ren, Ling1; Yang, Ke1
Corresponding AuthorRen, Ling(lren@imr.ac.cn)
2020-07-01
Source PublicationCERAMICS INTERNATIONAL
ISSN0272-8842
Volume46Issue:10Pages:14448-14459
AbstractThe aim of the present study is to examine the function of the two significant biological cations, Zn2+ and Sr2+, when co-doped in the structure of hydroxyapatite (HA). Six samples with different Zn2+ and Sr2+ concentrations were prepared by a hydrothermal process that includes the addition of Zn2+ and Sr2+ containing precursors to replace Ca2+ partially in the HA structure. The obtained nanomaterials were examined via XRD, ICP, FTIR, Raman spectroscopy, FESEM, TEM, and TGA for the investigation and confirmation of co-doping, crystallinity, phase purity, lattice parameters, elemental compositions, particle morphology, and thermal stability respectively. Interestingly the Zn2+ substitution increase with Sr2+ co-doping and the apatite structure going disappear up to 20% Zn10%Sr or 10%Zn20%Sr in the solution. Furthermore, in vitro cell viability even at high Zn2+ concentration (up to 6 wt %), MC3T3-E1 cells proliferated at a high rate on co-substituted HA materials, confirming that Sr2+ offset the cytotoxic effect of Zn2+ and increased the biocompatibility of the material. Moreover, the antibacterial effects of co-substituted HA against pathogen bacterial strains (E.coli and S.aureus) were also significantly increased. Overall results demonstrated that HA co-substituted by Zn2+ and Sr2+ at (10% Zn10%Sr-HA) is a potential material for hard tissue scaffolds.
KeywordCo-substituted hydroxyapatite Structural characterization In vitro bioactivity Antibacterial
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, CAS ; Promoting Liaoning Province Talents Program -Top Young Talents
DOI10.1016/j.ceramint.2020.02.242
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation of China[51631009] ; Youth Innovation Promotion Association, CAS[2014168] ; Promoting Liaoning Province Talents Program -Top Young Talents[XLYC1807069]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Ceramics
WOS IDWOS:000533511200013
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/139032
Collection中国科学院金属研究所
Corresponding AuthorRen, Ling
Affiliation1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China
3.NED Univ Engn & Technol, Dept Met Engn, Karachi, Pakistan
Recommended Citation
GB/T 7714
Ullah, Ihsan,Siddiqui, Muhammad Ali,Kolawole, Sharafadeen Kunle,et al. Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application[J]. CERAMICS INTERNATIONAL,2020,46(10):14448-14459.
APA Ullah, Ihsan.,Siddiqui, Muhammad Ali.,Kolawole, Sharafadeen Kunle.,Liu, Hui.,Zhang, Ji.,...&Yang, Ke.(2020).Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application.CERAMICS INTERNATIONAL,46(10),14448-14459.
MLA Ullah, Ihsan,et al."Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application".CERAMICS INTERNATIONAL 46.10(2020):14448-14459.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ullah, Ihsan]'s Articles
[Siddiqui, Muhammad Ali]'s Articles
[Kolawole, Sharafadeen Kunle]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ullah, Ihsan]'s Articles
[Siddiqui, Muhammad Ali]'s Articles
[Kolawole, Sharafadeen Kunle]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ullah, Ihsan]'s Articles
[Siddiqui, Muhammad Ali]'s Articles
[Kolawole, Sharafadeen Kunle]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.