| Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application | |
| Ullah, Ihsan1,2; Siddiqui, Muhammad Ali1,2,3; Kolawole, Sharafadeen Kunle1,2; Liu, Hui1,2; Zhang, Ji1; Ren, Ling1; Yang, Ke1 | |
| Corresponding Author | Ren, Ling(lren@imr.ac.cn) |
| 2020-07-01 | |
| Source Publication | CERAMICS INTERNATIONAL
 |
| ISSN | 0272-8842 |
| Volume | 46Issue:10Pages:14448-14459 |
| Abstract | The aim of the present study is to examine the function of the two significant biological cations, Zn2+ and Sr2+, when co-doped in the structure of hydroxyapatite (HA). Six samples with different Zn2+ and Sr2+ concentrations were prepared by a hydrothermal process that includes the addition of Zn2+ and Sr2+ containing precursors to replace Ca2+ partially in the HA structure. The obtained nanomaterials were examined via XRD, ICP, FTIR, Raman spectroscopy, FESEM, TEM, and TGA for the investigation and confirmation of co-doping, crystallinity, phase purity, lattice parameters, elemental compositions, particle morphology, and thermal stability respectively. Interestingly the Zn2+ substitution increase with Sr2+ co-doping and the apatite structure going disappear up to 20% Zn10%Sr or 10%Zn20%Sr in the solution. Furthermore, in vitro cell viability even at high Zn2+ concentration (up to 6 wt %), MC3T3-E1 cells proliferated at a high rate on co-substituted HA materials, confirming that Sr2+ offset the cytotoxic effect of Zn2+ and increased the biocompatibility of the material. Moreover, the antibacterial effects of co-substituted HA against pathogen bacterial strains (E.coli and S.aureus) were also significantly increased. Overall results demonstrated that HA co-substituted by Zn2+ and Sr2+ at (10% Zn10%Sr-HA) is a potential material for hard tissue scaffolds. |
| Keyword | Co-substituted hydroxyapatite Structural characterization In vitro bioactivity Antibacterial |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, CAS ; Promoting Liaoning Province Talents Program -Top Young Talents |
| DOI | 10.1016/j.ceramint.2020.02.242 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation of China[51631009] ; Youth Innovation Promotion Association, CAS[2014168] ; Promoting Liaoning Province Talents Program -Top Young Talents[XLYC1807069] |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Ceramics |
| WOS ID | WOS:000533511200013 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/139032 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Ren, Ling |
| Affiliation | 1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 3.NED Univ Engn & Technol, Dept Met Engn, Karachi, Pakistan |
| Recommended Citation GB/T 7714 | Ullah, Ihsan,Siddiqui, Muhammad Ali,Kolawole, Sharafadeen Kunle,et al. Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application[J]. CERAMICS INTERNATIONAL,2020,46(10):14448-14459. |
| APA | Ullah, Ihsan.,Siddiqui, Muhammad Ali.,Kolawole, Sharafadeen Kunle.,Liu, Hui.,Zhang, Ji.,...&Yang, Ke.(2020).Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application.CERAMICS INTERNATIONAL,46(10),14448-14459. |
| MLA | Ullah, Ihsan,et al."Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application".CERAMICS INTERNATIONAL 46.10(2020):14448-14459. |
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