Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer

doi:10.12659/MSM.922920

IMR OpenIR

	Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer
	Meng, Yingying 1,2; Zhang, Dan 1,2; Jia, Xingya 1,2; Xiao, Keshen 3; Lin, Xiao 4,5; Yang, Yi 6; Xu, Dake 6; Wang, Qiang 1,2
通讯作者	Jia, Xingya(jiaxingya_cmu@163.com) ; Lin, Xiao(xlin@suda.edu.cn) ; Wang, Qiang(mfqwang@163.com)
	2020-06-06
发表期刊	MEDICAL SCIENCE MONITOR
ISSN	1643-3750
卷号	26 页码:10
摘要	Background: The goal of the present work was to assess the antibacterial activity of nano-magnesium hydroxide (NMH) against Streptococcus mutans (S. mutans) and to explore the antimicrobial function of AH Plus (TM) sealer incorporating NMH. Material/Methods: The antimicrobial behavior of NMH against S. mutans was evaluated with bactericidal tests. A modified direct contact test was used to assess the antimicrobial activity of unset AH Plus containing NMH after 5 minutes, 20 minutes, and 60 minutes of contact with bacteria. The antimicrobial effects and the amount of surface-adhering bacteria of the solidified materials were explored by SEM and confocal laser scanning microscopy, respectively. Results: NMH powder presented excellent antimicrobial activity against S. mutans. Mg-2* and OH- were not the main fac- tors resulting in bacterial death. Approximately 93.1% and 98% of the S. mutans were killed in the AH Plus+7% NMH group after incubation for 5 minutes and 20 minutes, respectively. AH Plus with 5% or 7% NMH were more potent against S. mutans compared with AH Plus alone (P<0.05). Moreover, the antibacterial function of AH Plus was lost after setting. NMH enabled the solidified AH Plus to still have antibacterial properties on the seventh day. Conclusions: NMH can be used to modify AH Plus sealer to eradicate residual bacteria and prevent reinfection.
关键词	Magnesium Hydroxide Root Canal Therapy Streptococcus mutans
DOI	10.12659/MSM.922920
收录类别	SCI
语种	英语
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000538389900001
出版者	INT SCIENTIFIC INFORMATION, INC
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/139157
专题	中国科学院金属研究所
通讯作者	Jia, Xingya; Lin, Xiao; Wang, Qiang
作者单位	1.China Med Univ, Sch & Hosp Stomatol, Shenyang, Liaoning, Peoples R China 2.Liaoning Prov Key Lab Oral Dis, Shenyang, Liaoning, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 4.Soochow Univ, Affiliated Hosp 1, Orthopaed Inst, Suzhou, Jiangsu, Peoples R China 5.Soochow Univ, Affiliated Hosp 1, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China 6.Northeastern Univ, Key Lab Anisotropy & Texture Mat, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Meng, Yingying,Zhang, Dan,Jia, Xingya,et al. Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer[J]. MEDICAL SCIENCE MONITOR,2020,26:10.
APA	Meng, Yingying.,Zhang, Dan.,Jia, Xingya.,Xiao, Keshen.,Lin, Xiao.,...&Wang, Qiang.(2020).Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer.MEDICAL SCIENCE MONITOR,26,10.
MLA	Meng, Yingying,et al."Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer".MEDICAL SCIENCE MONITOR 26(2020):10.