| Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway | |
| Liu, Yunen1; Tong, Changci1; Tang, Yushan2; Cong, Peifang1; Liu, Ying1; Shi, Xiuyun1; Shi, Lin1; Zhao, Yan3; Jin, Hongxu1; Li, Jing4; Hou, Mingxiao1 | |
| Corresponding Author | Jin, Hongxu() ; Li, Jing() ; Hou, Mingxiao(houmingxiao188@163.com) |
| 2020-05-20 | |
| Source Publication | FREE RADICAL BIOLOGY AND MEDICINE
 |
| ISSN | 0891-5849 |
| Volume | 152Pages:52-60 |
| Abstract | Although Tanshinone IIA (Tan IIA) has been associated with inflammation, oxidative stress and apoptosis, the effects of Tan IIA on lung blast injury remain uncertain. In this study, we explored the effects of Tan IIA on lung blast injury, studied its possible molecular mechanisms. Fifty C57BL/6 mice were randomly divided into the control, blast, blast + Tan IIA, blast + LY294002 (a PI3K inhibitor), or blast + Tan IIA + LY294002 groups. Serum and lung samples were collected 48 h after blast injury. The data showed that Tan IIA significantly inhibited blast -induced increases in the lung weight/body weight and wet/dry (W/D) weight ratios, decreased the CD44 - and CD163-positive inflammatory cell infiltration in the lungs, reduced the IL-1 ?, TNF- ? and IL -6 expression, and enhanced IL -10 expression. Tan IIA also significantly alleviated the increases in MDA5 and IRE -a and the decrease in SOD -1 and reversed the low Bcl-2 expression and the high Bax and Caspase-3 expressions. Additionally, Tan IIA significantly decreased p-PI3K and p-Akt expression and increased p-FoxO1 expression. More importantly, both LY294002 and Tan IIA pretreatment markedly protected against blast -induced in- flammation, oxidative stress and apoptosis in lung blast injury. These results suggest that Tan IIA protects against lung blast injury, which may be partly mediated by inhibiting the PI3K/Akt/FoxO1 signaling pathway. |
| Keyword | Blast injury Tan IIA Acute lung injury Oxidative stress Inflammation PI3K Akt FoxO1 signaling pathway |
| Funding Organization | Liaoning Province Key Scientific and Technological Project ; PLA fundation of China |
| DOI | 10.1016/j.freeradbiomed.2020.02.032 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Liaoning Province Key Scientific and Technological Project[201602774] ; Liaoning Province Key Scientific and Technological Project[20170540947] ; PLA fundation of China[AWS14L008] ; PLA fundation of China[CSY13J003] ; PLA fundation of China[BWS16J010] |
| WOS Research Area | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS Subject | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS ID | WOS:000542948900006 |
| Publisher | ELSEVIER SCIENCE INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/139391 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Jin, Hongxu; Li, Jing; Hou, Mingxiao |
| Affiliation | 1.Gen Hosp Northern Theater Command, Lab Rescue Ctr Severe Trauma PLA, Dept Emergency Med, 83 Roacl, Shenyang 110016, Peoples R China 2.Chinese Med Univ, Coll Life Sci, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 4.Gen Hosp Northern Theater Command, Dept Cadre Ward 2, Shenyang 110016, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Yunen,Tong, Changci,Tang, Yushan,et al. Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway[J]. FREE RADICAL BIOLOGY AND MEDICINE,2020,152:52-60. |
| APA | Liu, Yunen.,Tong, Changci.,Tang, Yushan.,Cong, Peifang.,Liu, Ying.,...&Hou, Mingxiao.(2020).Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway.FREE RADICAL BIOLOGY AND MEDICINE,152,52-60. |
| MLA | Liu, Yunen,et al."Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway".FREE RADICAL BIOLOGY AND MEDICINE 152(2020):52-60. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment