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Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway
Liu, Yunen1; Tong, Changci1; Tang, Yushan2; Cong, Peifang1; Liu, Ying1; Shi, Xiuyun1; Shi, Lin1; Zhao, Yan3; Jin, Hongxu1; Li, Jing4; Hou, Mingxiao1
Corresponding AuthorJin, Hongxu() ; Li, Jing() ; Hou, Mingxiao(houmingxiao188@163.com)
2020-05-20
Source PublicationFREE RADICAL BIOLOGY AND MEDICINE
ISSN0891-5849
Volume152Pages:52-60
AbstractAlthough Tanshinone IIA (Tan IIA) has been associated with inflammation, oxidative stress and apoptosis, the effects of Tan IIA on lung blast injury remain uncertain. In this study, we explored the effects of Tan IIA on lung blast injury, studied its possible molecular mechanisms. Fifty C57BL/6 mice were randomly divided into the control, blast, blast + Tan IIA, blast + LY294002 (a PI3K inhibitor), or blast + Tan IIA + LY294002 groups. Serum and lung samples were collected 48 h after blast injury. The data showed that Tan IIA significantly inhibited blast -induced increases in the lung weight/body weight and wet/dry (W/D) weight ratios, decreased the CD44 - and CD163-positive inflammatory cell infiltration in the lungs, reduced the IL-1 ?, TNF- ? and IL -6 expression, and enhanced IL -10 expression. Tan IIA also significantly alleviated the increases in MDA5 and IRE -a and the decrease in SOD -1 and reversed the low Bcl-2 expression and the high Bax and Caspase-3 expressions. Additionally, Tan IIA significantly decreased p-PI3K and p-Akt expression and increased p-FoxO1 expression. More importantly, both LY294002 and Tan IIA pretreatment markedly protected against blast -induced in- flammation, oxidative stress and apoptosis in lung blast injury. These results suggest that Tan IIA protects against lung blast injury, which may be partly mediated by inhibiting the PI3K/Akt/FoxO1 signaling pathway.
KeywordBlast injury Tan IIA Acute lung injury Oxidative stress Inflammation PI3K Akt FoxO1 signaling pathway
Funding OrganizationLiaoning Province Key Scientific and Technological Project ; PLA fundation of China
DOI10.1016/j.freeradbiomed.2020.02.032
Indexed BySCI
Language英语
Funding ProjectLiaoning Province Key Scientific and Technological Project[201602774] ; Liaoning Province Key Scientific and Technological Project[20170540947] ; PLA fundation of China[AWS14L008] ; PLA fundation of China[CSY13J003] ; PLA fundation of China[BWS16J010]
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000542948900006
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/139391
Collection中国科学院金属研究所
Corresponding AuthorJin, Hongxu; Li, Jing; Hou, Mingxiao
Affiliation1.Gen Hosp Northern Theater Command, Lab Rescue Ctr Severe Trauma PLA, Dept Emergency Med, 83 Roacl, Shenyang 110016, Peoples R China
2.Chinese Med Univ, Coll Life Sci, Shenyang 110001, Peoples R China
3.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
4.Gen Hosp Northern Theater Command, Dept Cadre Ward 2, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yunen,Tong, Changci,Tang, Yushan,et al. Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway[J]. FREE RADICAL BIOLOGY AND MEDICINE,2020,152:52-60.
APA Liu, Yunen.,Tong, Changci.,Tang, Yushan.,Cong, Peifang.,Liu, Ying.,...&Hou, Mingxiao.(2020).Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway.FREE RADICAL BIOLOGY AND MEDICINE,152,52-60.
MLA Liu, Yunen,et al."Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway".FREE RADICAL BIOLOGY AND MEDICINE 152(2020):52-60.
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