IMR OpenIR
Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis
Yang, Hongwei1; Yu, Meng1,2; Wang, Rong1; Li, Bo1,2; Zhao, Xin1; Hao, Yulin3; Guo, Zheng4; Han, Yong1
Corresponding AuthorHan, Yong(yonghan@mail.xjtu.edu.cn)
2020-10-15
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Volume116Pages:400-414
AbstractCurrent bioactive modifications of Ti-based materials for promoting osteogenesis often decrease corrosion fatigue strength (sigma(cf)) of the resultant implants, thereby shortening their service lifespan. To solve this issue and accelerate the osteogenesis process, in the present study, a TiO 2 nanorods (TNR)-arrayed coating was hydrothermally grown on optimal surface mechanical attrition treated (SMATed) titanium (S-Ti). The microstructure, bond integrity, residual stress distribution, and corrosion fatigue of TNR-coated S-Ti (TNR/S-Ti) and the response of macrophages and bone marrow-derived mesenchymal stem cells (BMSCs) to TNR/S-Ti were investigated and compared with those of mechanically polished Ti (P-Ti), S-Ti, and TNR-coated P-Ti (TNR/P-Ti). S-Ti showed a nanograined layer and an underlying grain-deformed region with residual compressive stress, which was sustained even when it was hydrothermally coated with TNR. TNR on S-Ti showed nanotopography, composition, and bond strength almost identical to those of P-Ti. While TNR/P-Ti showed a considerable decrease in a ci , compared to P-Ti, TNR/S-Ti exhibited an improved sigma-cf which was even higher than that of P-Ti. Biologically, TNR/S-Ti enhanced adhesion, differentiation, and mineralization of BMSCs, and it also promoted adhesion and M1-to-M2 transition of macrophages as compared to S-Ti and P-Ti. With rapid phenotype switch of macrophages, the level of proinflammatory cytokines decreased, while anti-inflammatory cytokines were upregulated. In co-culture conditions, the migration, differentiation, and mineralization of BMSCs were enhanced by increased level of secretion factors of macrophages on TNR/S-Ti. The modified structure accelerated bone apposition in rabbit femur and is expected to induce a favorable immune microenvironment to facilitate osseointegration earlier; it can also simultaneously improve corrosion fatigue resistance of Ti-based implants and thereby enhance their service life. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
KeywordSurface mechanical attrition treatment TiO2 nanorods arrayed coating Corrosion fatigue Immunomodulation Osteogenesis
Funding OrganizationNational Natural Science Foundation of China ; China Postdoctoral Science Foundation
DOI10.1016/j.actbio.2020.09.005
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[51631007] ; National Natural Science Foundation of China[51971171] ; National Natural Science Foundation of China[81901893] ; China Postdoctoral Science Foundation[2018M643631]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000577516000027
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/140945
Collection中国科学院金属研究所
Corresponding AuthorHan, Yong
Affiliation1.Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China
2.Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Sch Life Sci & Technol, Xian 710049, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
4.Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Peoples R China
Recommended Citation
GB/T 7714
Yang, Hongwei,Yu, Meng,Wang, Rong,et al. Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis[J]. ACTA BIOMATERIALIA,2020,116:400-414.
APA Yang, Hongwei.,Yu, Meng.,Wang, Rong.,Li, Bo.,Zhao, Xin.,...&Han, Yong.(2020).Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis.ACTA BIOMATERIALIA,116,400-414.
MLA Yang, Hongwei,et al."Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis".ACTA BIOMATERIALIA 116(2020):400-414.
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