Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis

doi:10.1016/j.msec.2020.110903

IMR OpenIR

	Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis
	Luo, J. P.1,2,3; Huang, Y. J.3; Xu, J. Y.1,2,4; Sun, J. F.3; Dargusch, M. S.4; Hou, C. H.5; Ren, L.6; Wang, R. Z.7; Ebel, T.8; Yan, M.1,2
通讯作者	Sun, J. F.(jfsun@hit.edu.cn) ; Yan, M.(yanm@sustech.edu.cn)
	2020-09-01
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
卷号	114 页码:16
摘要	Some beta-Ti alloys, such as Ti-Nb-Ta-Zr (TNTZ) alloys, exhibit a low Young's modulus and excellent biocompatibility. These alloys are promising new generation biomedical implant materials. Selective laser melting (SLM) can further enable customer-specific manufacturing of beta-Ti alloys to satisfy the ever-increasing need for enhanced biomedical products. In this study, we quantitatively determined the relationships between porosity, yield strength, and Young's modulus of SLM-prepared TNTZ lattices. The study constitutes a critical step toward understanding the behavior of the lattice and eventually enables tuning the Young's modulus to match that of human bones. Fatigue properties were also investigated on as-printed lattices in terms of the stress limit. The biocompatibility study included a routine evaluation of the relative cell growth rate and a proteomics analysis using a common mouse fibroblast cell line, L929. The results indicated that the as-printed TNTZ samples exhibited evidence of protein proliferation of the L929 cells, particularly P06733, and that those proteins are responsible for biological processes and molecular functions. They in turn may have promoted cell regeneration, cell motility, and protein binding, which at least partially explains the good biocompatibility of the as-printed TNTZ at the protein level. The study highlights the promising applications of additively manufactured TNTZ as a bone-replacing material from mechanical and biocompatibility perspectives.
关键词	Selective laser melting Ti-Nb-Ta-Zr (TNTZ) Mechanical properties Biocompatibility Proteomics
资助者	Science, Technology and Innovation Commission of Shenzhen Municipality ; Science Foundation of Guangdong Province ; Humboldt Foundation Research Fellowship for Experienced Researchers ; Pico Center at SUSTech ; Presidential Fund and Development and Reform Commission of Shenzhen Municipality ; Australian Research Council through the ARC Research Hub for Advanced Manufacturing of Medical Devices
DOI	10.1016/j.msec.2020.110903
收录类别	SCI
语种	英语
资助项目	Science, Technology and Innovation Commission of Shenzhen Municipality[ZDSYS201703031748354] ; Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20150529152146478] ; Science Foundation of Guangdong Province[2016A030313756] ; Humboldt Foundation Research Fellowship for Experienced Researchers ; Pico Center at SUSTech ; Presidential Fund and Development and Reform Commission of Shenzhen Municipality ; Australian Research Council through the ARC Research Hub for Advanced Manufacturing of Medical Devices[IH1501000024]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000579654700011
出版者	ELSEVIER
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/141040
专题	中国科学院金属研究所
通讯作者	Sun, J. F.; Yan, M.
作者单位	1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Key Lab Addit Mfg High Performance Mat, Shenzhen 518055, Peoples R China 3.Harbin Inst Technol, Sch Mat Sci & Engn, Harbin 150001, Peoples R China 4.Univ Queensland, Sch Mech & Min Engn, Brisbane, Qld 4072, Australia 5.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China 6.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 7.Univ British Columbia, Dept Mat Engn, Vancouver, BC V6T 1Z4, Canada 8.Helmholtz Zentrum Geesthacht, Inst Mat Res, D-21502 Geesthacht, Germany
推荐引用方式 GB/T 7714	Luo, J. P.,Huang, Y. J.,Xu, J. Y.,et al. Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,114:16.
APA	Luo, J. P..,Huang, Y. J..,Xu, J. Y..,Sun, J. F..,Dargusch, M. S..,...&Yan, M..(2020).Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,114,16.
MLA	Luo, J. P.,et al."Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 114(2020):16.