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Promoter hypermethylation of KiSS-1 gene in gastric cancer
Alternative TitlePromoter Hypermethylation of KiSS-1 Gene in Gastric Cancer
Yang Zhi; Dai DongQiu; Du YunYi
2010
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume22Issue:4Pages:280-284
AbstractTo investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer and evaluate the role of peritoneal lavage fluid in detecting peritoneal metastases.
Other AbstractObjective:To investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer and evaluate the role of peritoneal lavage fluid in detecting peritoneal metastases. Methods:The methylation status of KiSS-1 gene in 40 gastric cancer specimens,the corresponding adjacent normal mucosa,lymph nodes and peritoneal lavage fluid was investigated by methylation-spcific polymerase chain reaction(MS-PCR). Results:Aberrant methylation of KiSS-1 gene was detected in 55%(22/40)of the adjacent normal mucosa,82.5%(33/40)of gastric cancer specimens,80.95%(17/21)of the lymph nodes,and 42.5%(17/40) of peritoneal lavage fluid.Methylation in gastric carcinoma and lymphonode was more frequent than in non-neoplastic gastiric mucosa.Presence of KiSS-1 methylation in peritoneal lavage fluid was significantly correlated with tumor invasion(P=0.043).The accuracy of KiSS-1 methylation in peritoneal lavage fluid for diagnosing peritoneal metastasis was 70%,with a sensitivity of 77.8%and a specificity of 67.7%. Conclusion:Aberrant methylation of KiSS-1 gene is a common event in the occurrence and progression of gastric carcinoma,which may provide useful information for the early diagnosis of peritoneal metastases and a new therapy for gastric cancer
KeywordLUNG-CANCER PERITONEAL-LAVAGE COLORECTAL-CANCER MULTIPLE GENES BREAST-CANCER TUMOR-CELLS METHYLATION DNA EXPRESSION CARCINOMA Gastric cancer Methylation KiSS-1 Peritoneal lavage fluid
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Science Foundation for High Education]
CSCD IDCSCD:4075598
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/141845
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Yang Zhi,Dai DongQiu,Du YunYi. Promoter hypermethylation of KiSS-1 gene in gastric cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(4):280-284.
APA Yang Zhi,Dai DongQiu,&Du YunYi.(2010).Promoter hypermethylation of KiSS-1 gene in gastric cancer.CHINESE JOURNAL OF CANCER RESEARCH,22(4),280-284.
MLA Yang Zhi,et al."Promoter hypermethylation of KiSS-1 gene in gastric cancer".CHINESE JOURNAL OF CANCER RESEARCH 22.4(2010):280-284.
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