| Promoter hypermethylation of KiSS-1 gene in gastric cancer | |
| Alternative Title | Promoter Hypermethylation of KiSS-1 Gene in Gastric Cancer |
| Yang Zhi; Dai DongQiu; Du YunYi | |
| 2010 | |
| Source Publication | CHINESE JOURNAL OF CANCER RESEARCH
 |
| ISSN | 1000-9604 |
| Volume | 22Issue:4Pages:280-284 |
| Abstract | To investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer and evaluate the role of peritoneal lavage fluid in detecting peritoneal metastases. |
| Other Abstract | Objective:To investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer and evaluate the role of peritoneal lavage fluid in detecting peritoneal metastases. Methods:The methylation status of KiSS-1 gene in 40 gastric cancer specimens,the corresponding adjacent normal mucosa,lymph nodes and peritoneal lavage fluid was investigated by methylation-spcific polymerase chain reaction(MS-PCR). Results:Aberrant methylation of KiSS-1 gene was detected in 55%(22/40)of the adjacent normal mucosa,82.5%(33/40)of gastric cancer specimens,80.95%(17/21)of the lymph nodes,and 42.5%(17/40) of peritoneal lavage fluid.Methylation in gastric carcinoma and lymphonode was more frequent than in non-neoplastic gastiric mucosa.Presence of KiSS-1 methylation in peritoneal lavage fluid was significantly correlated with tumor invasion(P=0.043).The accuracy of KiSS-1 methylation in peritoneal lavage fluid for diagnosing peritoneal metastasis was 70%,with a sensitivity of 77.8%and a specificity of 67.7%. Conclusion:Aberrant methylation of KiSS-1 gene is a common event in the occurrence and progression of gastric carcinoma,which may provide useful information for the early diagnosis of peritoneal metastases and a new therapy for gastric cancer |
| Keyword | LUNG-CANCER PERITONEAL-LAVAGE COLORECTAL-CANCER MULTIPLE GENES BREAST-CANCER TUMOR-CELLS METHYLATION DNA EXPRESSION CARCINOMA Gastric cancer Methylation KiSS-1 Peritoneal lavage fluid |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Science Foundation for High Education] |
| CSCD ID | CSCD:4075598 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/141845 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Yang Zhi,Dai DongQiu,Du YunYi. Promoter hypermethylation of KiSS-1 gene in gastric cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(4):280-284. |
| APA | Yang Zhi,Dai DongQiu,&Du YunYi.(2010).Promoter hypermethylation of KiSS-1 gene in gastric cancer.CHINESE JOURNAL OF CANCER RESEARCH,22(4),280-284. |
| MLA | Yang Zhi,et al."Promoter hypermethylation of KiSS-1 gene in gastric cancer".CHINESE JOURNAL OF CANCER RESEARCH 22.4(2010):280-284. |
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