Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats

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	Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats
其他题名	Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats ☆
	Yang Xiyao 1; Zhu Feng 1; Zhang Xiaomei 2; Gao Zhuo 1; Cao Yunpeng 1
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:34 页码:2698-2704
摘要	We investigated the effects of ipsilateral versus bilateral limb-training on promotion of endogenous neural stem cells in the peripheral infarct zone and the corresponding cerebral region in the unaffected hemisphere of rats with cerebral infarction. Middle cerebral artery occlusion was induced in Wistar rats. The rat forelimb on the unaffected side was either wrapped up with tape to force the use of the paretic forelimb in rats or not braked to allow bilateral forelimbs to participate in training. Daily training consisted of mesh drum training, balance beam training, and stick rolling training for a total of 40 minutes, once per day. Control rats received no training. At 14 days after functional training, rats receiving bilateral limb-training exhibited milder neurological impairment than that in the ipsilateral limb-training group or the control group. The number of nestin/glial fibrillary acidic protein-positive and nestin/microtubule-associated protein 2-positive cells in the peripheral infarct zone and in the corresponding cerebral region in the unaffected hemisphere was significantly higher in rats receiving bilateral limb-training than in rats receiving ipsilateral limb-training. These data suggest that bilateral limb-training can promote the proliferation and differentiation of endogenous neural stem cells in the bilateral hemispheres after cerebral infarction and accelerate the recovery of neurologic function. In addition, bilateral limb-training produces better therapeutic effects than ipsilateral limb-training.
其他摘要	We investigated the effects of ipsilateral versus bilateral limb-training on promotion of endogenous neural stem cells in the peripheral infarct zone and the corresponding cerebral region in the unaffected hemisphere of rats with cerebral infarction. Middle cerebral artery occlusion was induced in Wistar rats. The rat forelimb on the unaffected side was either wrapped up with tape to force the use of the paretic forelimb in rats or not braked to allow bilateral forelimbs to participate in training. Daily training consisted of mesh drum training, balance beam training, and stick rolling training for a total of 40 minutes, once per day. Control rats received no training. At 14 days after functional training, rats receiving bilateral limb-training exhibited milder neurological impairment than that in the ipsilateral limb-training group or the control group. The number of nestin
关键词	UNAFFECTED HEMISPHERE ARTERY OCCLUSION CHRONIC STROKE PROGENITOR CELLS RECOVERY CORTEX GFAP DISINHIBITION STIMULATION HIPPOCAMPUS bilateral rehabilitation training affected limb bilateral limbs peripheral infarct zone unaffected hemisphere middle cerebral artery occlusion brain neural stem cells proliferation differentiation plasticity neural regeneration
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4747649
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/141885
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.First Peoples Hosp Dandong, Dandong 118000, Liaoning Provin, Peoples R China
推荐引用方式 GB/T 7714	Yang Xiyao,Zhu Feng,Zhang Xiaomei,et al. Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(34):2698-2704.
APA	Yang Xiyao,Zhu Feng,Zhang Xiaomei,Gao Zhuo,&Cao Yunpeng.(2012).Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats.NEURAL REGENERATION RESEARCH,7(34),2698-2704.
MLA	Yang Xiyao,et al."Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats".NEURAL REGENERATION RESEARCH 7.34(2012):2698-2704.