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Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats
Alternative TitleIpsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats ☆
Yang Xiyao1; Zhu Feng1; Zhang Xiaomei2; Gao Zhuo1; Cao Yunpeng1
2012
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume7Issue:34Pages:2698-2704
AbstractWe investigated the effects of ipsilateral versus bilateral limb-training on promotion of endogenous neural stem cells in the peripheral infarct zone and the corresponding cerebral region in the unaffected hemisphere of rats with cerebral infarction. Middle cerebral artery occlusion was induced in Wistar rats. The rat forelimb on the unaffected side was either wrapped up with tape to force the use of the paretic forelimb in rats or not braked to allow bilateral forelimbs to participate in training. Daily training consisted of mesh drum training, balance beam training, and stick rolling training for a total of 40 minutes, once per day. Control rats received no training. At 14 days after functional training, rats receiving bilateral limb-training exhibited milder neurological impairment than that in the ipsilateral limb-training group or the control group. The number of nestin/glial fibrillary acidic protein-positive and nestin/microtubule-associated protein 2-positive cells in the peripheral infarct zone and in the corresponding cerebral region in the unaffected hemisphere was significantly higher in rats receiving bilateral limb-training than in rats receiving ipsilateral limb-training. These data suggest that bilateral limb-training can promote the proliferation and differentiation of endogenous neural stem cells in the bilateral hemispheres after cerebral infarction and accelerate the recovery of neurologic function. In addition, bilateral limb-training produces better therapeutic effects than ipsilateral limb-training.
Other AbstractWe investigated the effects of ipsilateral versus bilateral limb-training on promotion of endogenous neural stem cells in the peripheral infarct zone and the corresponding cerebral region in the unaffected hemisphere of rats with cerebral infarction. Middle cerebral artery occlusion was induced in Wistar rats. The rat forelimb on the unaffected side was either wrapped up with tape to force the use of the paretic forelimb in rats or not braked to allow bilateral forelimbs to participate in training. Daily training consisted of mesh drum training, balance beam training, and stick rolling training for a total of 40 minutes, once per day. Control rats received no training. At 14 days after functional training, rats receiving bilateral limb-training exhibited milder neurological impairment than that in the ipsilateral limb-training group or the control group. The number of nestin
KeywordUNAFFECTED HEMISPHERE ARTERY OCCLUSION CHRONIC STROKE PROGENITOR CELLS RECOVERY CORTEX GFAP DISINHIBITION STIMULATION HIPPOCAMPUS bilateral rehabilitation training affected limb bilateral limbs peripheral infarct zone unaffected hemisphere middle cerebral artery occlusion brain neural stem cells proliferation differentiation plasticity neural regeneration
Indexed ByCSCD
Language英语
CSCD IDCSCD:4747649
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/141885
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.First Peoples Hosp Dandong, Dandong 118000, Liaoning Provin, Peoples R China
Recommended Citation
GB/T 7714
Yang Xiyao,Zhu Feng,Zhang Xiaomei,et al. Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(34):2698-2704.
APA Yang Xiyao,Zhu Feng,Zhang Xiaomei,Gao Zhuo,&Cao Yunpeng.(2012).Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats.NEURAL REGENERATION RESEARCH,7(34),2698-2704.
MLA Yang Xiyao,et al."Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats".NEURAL REGENERATION RESEARCH 7.34(2012):2698-2704.
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