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MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE
Wang Hao1; Song Hongrui1; Cui Yong1; Deng Yingjie1; Chen Xuesi2
2011
Source PublicationCHINESE JOURNAL OF POLYMER SCIENCE
ISSN0256-7679
Volume29Issue:2Pages:173-179
AbstractUltra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly(ethylene glycol) blocked poly(L-lactide). Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry. According to in vitro drug release investigation by high performance liquid chromatography, it was found that fibers with 10%, 20% and 30% drug entrapped respect to polymer (mass ratio) presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K. The reason may be that fibers with 10% drug entrapped was more easily affected by enzyme while, to some degree, magnolol in fibers with 20% and 30% entrapped prevented polymer from being degraded by enzyme.
KeywordBIOMEDICAL APPLICATIONS BLOCK-COPOLYMERS FIBERS GLYCOL) ACID) Medicated fiber Electrospinning Drug release Poly(ethylene glycol) Polylactide Magnolol Proteinase K
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Chinese Academy of Sciences]
CSCD IDCSCD:4144350
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/141902
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.中山大学
Recommended Citation
GB/T 7714
Wang Hao,Song Hongrui,Cui Yong,et al. MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2011,29(2):173-179.
APA Wang Hao,Song Hongrui,Cui Yong,Deng Yingjie,&Chen Xuesi.(2011).MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE.CHINESE JOURNAL OF POLYMER SCIENCE,29(2),173-179.
MLA Wang Hao,et al."MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE".CHINESE JOURNAL OF POLYMER SCIENCE 29.2(2011):173-179.
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