MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE

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	MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE
	Wang Hao 1; Song Hongrui 1; Cui Yong 1; Deng Yingjie 1; Chen Xuesi 2
	2011
发表期刊	CHINESE JOURNAL OF POLYMER SCIENCE
ISSN	0256-7679
卷号	29 期号:2 页码:173-179
摘要	Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly(ethylene glycol) blocked poly(L-lactide). Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry. According to in vitro drug release investigation by high performance liquid chromatography, it was found that fibers with 10%, 20% and 30% drug entrapped respect to polymer (mass ratio) presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K. The reason may be that fibers with 10% drug entrapped was more easily affected by enzyme while, to some degree, magnolol in fibers with 20% and 30% entrapped prevented polymer from being degraded by enzyme.
关键词	BIOMEDICAL APPLICATIONS BLOCK-COPOLYMERS FIBERS GLYCOL) ACID) Medicated fiber Electrospinning Drug release Poly(ethylene glycol) Polylactide Magnolol Proteinase K
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Chinese Academy of Sciences]
CSCD记录号	CSCD:4144350
引用统计	被引频次：6[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/141902
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中山大学
推荐引用方式 GB/T 7714	Wang Hao,Song Hongrui,Cui Yong,et al. MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2011,29(2):173-179.
APA	Wang Hao,Song Hongrui,Cui Yong,Deng Yingjie,&Chen Xuesi.(2011).MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE.CHINESE JOURNAL OF POLYMER SCIENCE,29(2),173-179.
MLA	Wang Hao,et al."MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE".CHINESE JOURNAL OF POLYMER SCIENCE 29.2(2011):173-179.