A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid

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	A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid
其他题名	A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid
	Zhang Yong 1; Khan M Naseer A 1; Gong Ping 3; Lee Yong Sup 1
	2009
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	20 期号:8 页码:898-900
摘要	A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors. (C) 2009 Yong Sup Lee. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors.
关键词	ETHYL-ESTER REDUCTION 2-Hydroxy-4-oxo-4-phenylbutanoates Malic acid Friedel-Crafts reaction
收录类别	CSCD
语种	英语
资助项目	[Seoul Research and Business Development Program] ; [post-BK21 program, Korea]
CSCD记录号	CSCD:3651020
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/141938
专题	中国科学院金属研究所
作者单位	1.Kyung Hee Univ, Coll Pharm, Kyung Hee EW Pharmaceut Res Institute, Seoul 130701, South Korea 2.庆熙大学 3.中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhang Yong,Khan M Naseer A,Gong Ping,et al. A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid[J]. CHINESE CHEMICAL LETTERS,2009,20(8):898-900.
APA	Zhang Yong,Khan M Naseer A,Gong Ping,&Lee Yong Sup.(2009).A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid.CHINESE CHEMICAL LETTERS,20(8),898-900.
MLA	Zhang Yong,et al."A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid".CHINESE CHEMICAL LETTERS 20.8(2009):898-900.