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A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid
Alternative TitleA convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid
Zhang Yong1; Khan M Naseer A1; Gong Ping3; Lee Yong Sup1
2009
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume20Issue:8Pages:898-900
AbstractA synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors. (C) 2009 Yong Sup Lee. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors.
KeywordETHYL-ESTER REDUCTION 2-Hydroxy-4-oxo-4-phenylbutanoates Malic acid Friedel-Crafts reaction
Indexed ByCSCD
Language英语
Funding Project[Seoul Research and Business Development Program] ; [post-BK21 program, Korea]
CSCD IDCSCD:3651020
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/141940
Collection中国科学院金属研究所
Affiliation1.Kyung Hee Univ, Coll Pharm, Kyung Hee EW Pharmaceut Res Institute, Seoul 130701, South Korea
2.庆熙大学
3.中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhang Yong,Khan M Naseer A,Gong Ping,et al. A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid[J]. CHINESE CHEMICAL LETTERS,2009,20(8):898-900.
APA Zhang Yong,Khan M Naseer A,Gong Ping,&Lee Yong Sup.(2009).A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid.CHINESE CHEMICAL LETTERS,20(8),898-900.
MLA Zhang Yong,et al."A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid".CHINESE CHEMICAL LETTERS 20.8(2009):898-900.
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