| A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid | |
| Alternative Title | A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid |
| Zhang Yong1; Khan M Naseer A1; Gong Ping3; Lee Yong Sup1 | |
| 2009 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 20Issue:8Pages:898-900 |
| Abstract | A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors. (C) 2009 Yong Sup Lee. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Other Abstract | A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors. |
| Keyword | ETHYL-ESTER REDUCTION 2-Hydroxy-4-oxo-4-phenylbutanoates Malic acid Friedel-Crafts reaction |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Seoul Research and Business Development Program] ; [post-BK21 program, Korea] |
| CSCD ID | CSCD:3651020 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/141940 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Kyung Hee Univ, Coll Pharm, Kyung Hee EW Pharmaceut Res Institute, Seoul 130701, South Korea 2.庆熙大学 3.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhang Yong,Khan M Naseer A,Gong Ping,et al. A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid[J]. CHINESE CHEMICAL LETTERS,2009,20(8):898-900. |
| APA | Zhang Yong,Khan M Naseer A,Gong Ping,&Lee Yong Sup.(2009).A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid.CHINESE CHEMICAL LETTERS,20(8),898-900. |
| MLA | Zhang Yong,et al."A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates from malic acid".CHINESE CHEMICAL LETTERS 20.8(2009):898-900. |
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