Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis

IMR OpenIR

	Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis
其他题名	Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis
	Liu JiaLi 1; Liang Yuan 2; Wang ZhenNing 1; Zhou Xin 1; Xing LiLi 2
	2010
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
卷号	16 期号:43 页码:5510-5517
摘要	AIM: To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis.
其他摘要	AIM: To investigate the association of the cyclooxygenases-2(COX-2)polymorphisms and susceptibility to gastric cancer(GC)by means of meta-analysis. METHODS: Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE,EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR)with 95%confidence interval(CI)was calculated. RESULTS: Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C,-1195A, -1290G,2430T alleles and429TT genotype revealed increased risk for GC(OR=1.71,95%CI:1.01-2.90,P =0.05;OR=1.58,95%CI:1.05-2.38,P=0.03;OR= 1.55,95%CI:1.01-2.39,P=0.05;OR=2.62,95%CI: 1.20-5.73,P=0.02 and OR=0.74,95%CI:0.59-0.95, P=0.02, respectively). CONCLUSION: The-765C,-1195A,-1290G,2430T alleles and429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC
关键词	GASTROINTESTINAL-TRACT CANCER EXPRESSION ADENOCARCINOMA COX-2 CARCINOGENESIS EPIDEMIOLOGY ANGIOGENESIS INFLAMMATION RISK Cyclooxygenases-2 Gastric cancer Polymorphisms Susceptibility Meta-analysis
收录类别	CSCD
语种	英语
资助项目	[National Science Foundation of China] ; [Education Department of Liaoning Province]
CSCD记录号	CSCD:4051416
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/142222
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院南海海洋研究所
推荐引用方式 GB/T 7714	Liu JiaLi,Liang Yuan,Wang ZhenNing,et al. Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(43):5510-5517.
APA	Liu JiaLi,Liang Yuan,Wang ZhenNing,Zhou Xin,&Xing LiLi.(2010).Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis.WORLD JOURNAL OF GASTROENTEROLOGY,16(43),5510-5517.
MLA	Liu JiaLi,et al."Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis".WORLD JOURNAL OF GASTROENTEROLOGY 16.43(2010):5510-5517.