| Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis | |
| Alternative Title | Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis |
| Lyu Yani; Zhu Lili; Qi Ruiqun; Xu Jing; Di Zhenghong; Chen Hongduo; Gao Xinghua | |
| 2014 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 127Issue:12Pages:2389-2391 |
| Abstract | Suppressor of cytokine signaling 3 (SOCS3) proteins, a member of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors.However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance.Signal transducer and activator of transcription (STAT) proteins, a group of transcription factor, are critical for mediating signals during Th1, Th2, Treg, and Th17 differentiation.Recent study demonstrated that STAT3 is not only required for the differentiation of Th17, IL-6-activated STAT3 promotes Maf expression, a factor required for Th2 differentiation and production of IL-4.Furthermore, STAT3 was activated throughout Th2 cell differentiation and was indispensable for Th2 cytokine production and transcription factor expression.2 SOCS proteins were recognized to negatively regulate the JAK/ STAT signaling pathway through the common SH2 domain.Since binding of the SH2 domain of SOCS3 is relatively specific to receptors for STAT3-activating cytokines, such as IL-6, granulocyte-colony stimulating factor, leptin, and leukemia inhibitory factor, the suppressive effect of SOCS3 has been shown to be relatively restricted to STAT3.3 In this report we demonstrate that the serum levels of SOCS3 and STAT3 were increased in childhood atopic dermatitis (AD) compared with controls.Furthermore, STAT3 is significantly positively correlated with Scoring Atopic Dermatitis (SCORAD) index. |
| Other Abstract | Suppressor of cytokine signaling 3 (SOCS3) proteins, a member of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors.However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance.Signal transducer and activator of transcription (STAT) proteins, a group of transcription factor, are critical for mediating signals during Th1, Th2, Treg, and Th17 differentiation.Recent study demonstrated that STAT3 is not only required for the differentiation of Th17, IL-6-activated STAT3 promotes Maf expression, a factor required for Th2 differentiation and production of IL-4.Furthermore, STAT3 was activated throughout Th2 cell differentiation and was indispensable for Th2 cytokine production and transcription factor expression.2 SOCS proteins were recognized to negatively regulate the JAK/ STAT signaling pathway through the common SH2 domain.Since binding of the SH2 domain of SOCS3 is relatively specific to receptors for STAT3-activating cytokines, such as IL-6, granulocyte-colony stimulating factor, leptin, and leukemia inhibitory factor, the suppressive effect of SOCS3 has been shown to be relatively restricted to STAT3.3 In this report we demonstrate that the serum levels of SOCS3 and STAT3 were increased in childhood atopic dermatitis (AD) compared with controls.Furthermore, STAT3 is significantly positively correlated with Scoring Atopic Dermatitis (SCORAD) index. |
| Keyword | SOCS3 atopic dermatitis childhood SOCS3 STAT3 serum |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Public Welfare Research Fund for Healthcare] ; [Innovative Research Teams in Universities, Liaoning Bureau of Education] |
| CSCD ID | CSCD:5173803 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142232 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Lyu Yani,Zhu Lili,Qi Ruiqun,et al. Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis[J]. CHINESE MEDICAL JOURNAL,2014,127(12):2389-2391. |
| APA | Lyu Yani.,Zhu Lili.,Qi Ruiqun.,Xu Jing.,Di Zhenghong.,...&Gao Xinghua.(2014).Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis.CHINESE MEDICAL JOURNAL,127(12),2389-2391. |
| MLA | Lyu Yani,et al."Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis".CHINESE MEDICAL JOURNAL 127.12(2014):2389-2391. |
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