Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis

IMR OpenIR

	Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis
其他题名	Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis
	Lyu Yani; Zhu Lili; Qi Ruiqun; Xu Jing; Di Zhenghong; Chen Hongduo; Gao Xinghua
	2014
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	127 期号:12 页码:2389-2391
摘要	Suppressor of cytokine signaling 3 (SOCS3) proteins, a member of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors.However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance.Signal transducer and activator of transcription (STAT) proteins, a group of transcription factor, are critical for mediating signals during Th1, Th2, Treg, and Th17 differentiation.Recent study demonstrated that STAT3 is not only required for the differentiation of Th17, IL-6-activated STAT3 promotes Maf expression, a factor required for Th2 differentiation and production of IL-4.Furthermore, STAT3 was activated throughout Th2 cell differentiation and was indispensable for Th2 cytokine production and transcription factor expression.2 SOCS proteins were recognized to negatively regulate the JAK/ STAT signaling pathway through the common SH2 domain.Since binding of the SH2 domain of SOCS3 is relatively specific to receptors for STAT3-activating cytokines, such as IL-6, granulocyte-colony stimulating factor, leptin, and leukemia inhibitory factor, the suppressive effect of SOCS3 has been shown to be relatively restricted to STAT3.3 In this report we demonstrate that the serum levels of SOCS3 and STAT3 were increased in childhood atopic dermatitis (AD) compared with controls.Furthermore, STAT3 is significantly positively correlated with Scoring Atopic Dermatitis (SCORAD) index.
其他摘要	Suppressor of cytokine signaling 3 (SOCS3) proteins, a member of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors.However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance.Signal transducer and activator of transcription (STAT) proteins, a group of transcription factor, are critical for mediating signals during Th1, Th2, Treg, and Th17 differentiation.Recent study demonstrated that STAT3 is not only required for the differentiation of Th17, IL-6-activated STAT3 promotes Maf expression, a factor required for Th2 differentiation and production of IL-4.Furthermore, STAT3 was activated throughout Th2 cell differentiation and was indispensable for Th2 cytokine production and transcription factor expression.2 SOCS proteins were recognized to negatively regulate the JAK/ STAT signaling pathway through the common SH2 domain.Since binding of the SH2 domain of SOCS3 is relatively specific to receptors for STAT3-activating cytokines, such as IL-6, granulocyte-colony stimulating factor, leptin, and leukemia inhibitory factor, the suppressive effect of SOCS3 has been shown to be relatively restricted to STAT3.3 In this report we demonstrate that the serum levels of SOCS3 and STAT3 were increased in childhood atopic dermatitis (AD) compared with controls.Furthermore, STAT3 is significantly positively correlated with Scoring Atopic Dermatitis (SCORAD) index.
关键词	SOCS3 atopic dermatitis childhood SOCS3 STAT3 serum
收录类别	CSCD
语种	英语
资助项目	[Public Welfare Research Fund for Healthcare] ; [Innovative Research Teams in Universities, Liaoning Bureau of Education]
CSCD记录号	CSCD:5173803
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/142232
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Lyu Yani,Zhu Lili,Qi Ruiqun,et al. Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis[J]. CHINESE MEDICAL JOURNAL,2014,127(12):2389-2391.
APA	Lyu Yani.,Zhu Lili.,Qi Ruiqun.,Xu Jing.,Di Zhenghong.,...&Gao Xinghua.(2014).Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis.CHINESE MEDICAL JOURNAL,127(12),2389-2391.
MLA	Lyu Yani,et al."Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis".CHINESE MEDICAL JOURNAL 127.12(2014):2389-2391.