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Melatonin lowers edema after spinal cord injury
Alternative TitleMelatonin lowers edema after spinal cord injury
Li Cheng1; Chen Xiao1; Qiaol Suchi1; Liu Xinwei2; Liu Chang1; Zhu Degang1; Su Jiacan1; Wang Zhiwei1
2014
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume9Issue:24Pages:2205-2210
AbstractMelatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein.
Other AbstractMelatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg
KeywordRANDOMIZED CONTROLLED-TRIAL AQUAPORIN-4 EXPRESSION TIRILAZAD MESYLATE SECONDARY INJURY ISCHEMIC-INJURY NEURONAL DEATH WATER CHANNELS BRAIN EDEMA METHYLPREDNISOLONE RATS nerve regeneration spinal cord injury melatonin edema aquaporin glial fibrillary acidic protein immunohistochemistry western blot assay neural regeneration
Indexed ByCSCD
Language英语
Funding Project[China Postdoctoral Science Foundation Grant]
CSCD IDCSCD:5325093
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/142273
Collection中国科学院金属研究所
Affiliation1.Second Mil Med University, Changhai Hosp, Dept Orthoped Surg, Shanghai 200433, Peoples R China
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Li Cheng,Chen Xiao,Qiaol Suchi,et al. Melatonin lowers edema after spinal cord injury[J]. NEURAL REGENERATION RESEARCH,2014,9(24):2205-2210.
APA Li Cheng.,Chen Xiao.,Qiaol Suchi.,Liu Xinwei.,Liu Chang.,...&Wang Zhiwei.(2014).Melatonin lowers edema after spinal cord injury.NEURAL REGENERATION RESEARCH,9(24),2205-2210.
MLA Li Cheng,et al."Melatonin lowers edema after spinal cord injury".NEURAL REGENERATION RESEARCH 9.24(2014):2205-2210.
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