| Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma | |
| Alternative Title | Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma |
| Zhang Hao1; Zhang Shuilong1; Xu Huimian1 | |
| 2010 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 123Issue:24Pages:3728-3730 |
| Abstract | M azur and Clark introduced the term "gastrointestinal stromal tumor" (GIST).1 These tumors are thought to originate from mesenchymal stem cells that differentiate toward the interstitial cells of Cajal.2 Activation of c-kit or platelet-derived growth factor receptor alpha (PDGFRA) gene mutation has been shown to be a major force in GIST pathogenesis leading to down-stream phosphorylation of substrate proteins and subsequently activation of networks of signal transduction pathways that regulate cell proliferation, survival, apoptosis, motility and other important cell functions. Immunohistochemically, a great majority of GISTs show strong, diffuse c-kit expression. The diagnosis of GIST! is currently based on morphologic features and immunohistochemical demonstration of c-kit (CD117). However, in some cases c-kit immunoreactivity is weak or undetectable. Here we report a case of a c-kit negative mesenchymal neoplasm in which molecular analysis was required to establish the correct diagnosis of GIST. The synchronous appearance of c-kit positive GIST and other malignancies have been reported previously.3-6 To the best of our knowledge, this is the first report of a c-kit negative GIST of the stomach coexisting with a gastric adenocarcinoma |
| Other Abstract | M azur and Clark introduced the term "gastrointestinal stromal tumor" (GIST).1 These tumors are thought to originate from mesenchymal stem cells that differentiate toward the interstitial cells of Cajal.2 Activation of c-kit or platelet-derived growth factor receptor alpha (PDGFRA) gene mutation has been shown to be a major force in GIST pathogenesis leading to down-stream phosphorylation of substrate proteins and subsequently activation of networks of signal transduction pathways that regulate cell proliferation, survival, apoptosis, motility and other important cell functions. Immunohistochemically, a great majority of GISTs show strong, diffuse c-kit expression. The diagnosis of GIST! is currently based on morphologic features and immunohistochemical demonstration of c-kit (CD117). However, in some cases c-kit immunoreactivity is weak or undetectable. Here we report a case of a c-kit negative mesenchymal neoplasm in which molecular analysis was required to establish the correct diagnosis of GIST. The synchronous appearance of c-kit positive GIST and other malignancies have been reported previously.3-6 To the best of our knowledge, this is the first report of a c-kit negative GIST of the stomach coexisting with a gastric adenocarcinoma |
| Keyword | MUTATIONS DIAGNOSIS GISTS gastrointestinal stromal tumor gastric adenocarcinoma c-kit platelet-derived growth factor receptor alpha mutation |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:4088815 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142803 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.中国科学院合肥物质科学研究院肿瘤医院 |
| Recommended Citation GB/T 7714 | Zhang Hao,Zhang Shuilong,Xu Huimian. Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma[J]. CHINESE MEDICAL JOURNAL,2010,123(24):3728-3730. |
| APA | Zhang Hao,Zhang Shuilong,&Xu Huimian.(2010).Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma.CHINESE MEDICAL JOURNAL,123(24),3728-3730. |
| MLA | Zhang Hao,et al."Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma".CHINESE MEDICAL JOURNAL 123.24(2010):3728-3730. |
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