Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma

IMR OpenIR

	Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma
其他题名	Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma
	Zhang Hao 1; Zhang Shuilong 1; Xu Huimian 1
	2010
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	123 期号:24 页码:3728-3730
摘要	M azur and Clark introduced the term "gastrointestinal stromal tumor" (GIST).1 These tumors are thought to originate from mesenchymal stem cells that differentiate toward the interstitial cells of Cajal.2 Activation of c-kit or platelet-derived growth factor receptor alpha (PDGFRA) gene mutation has been shown to be a major force in GIST pathogenesis leading to down-stream phosphorylation of substrate proteins and subsequently activation of networks of signal transduction pathways that regulate cell proliferation, survival, apoptosis, motility and other important cell functions. Immunohistochemically, a great majority of GISTs show strong, diffuse c-kit expression. The diagnosis of GIST! is currently based on morphologic features and immunohistochemical demonstration of c-kit (CD117). However, in some cases c-kit immunoreactivity is weak or undetectable. Here we report a case of a c-kit negative mesenchymal neoplasm in which molecular analysis was required to establish the correct diagnosis of GIST. The synchronous appearance of c-kit positive GIST and other malignancies have been reported previously.3-6 To the best of our knowledge, this is the first report of a c-kit negative GIST of the stomach coexisting with a gastric adenocarcinoma
其他摘要	M azur and Clark introduced the term "gastrointestinal stromal tumor" (GIST).1 These tumors are thought to originate from mesenchymal stem cells that differentiate toward the interstitial cells of Cajal.2 Activation of c-kit or platelet-derived growth factor receptor alpha (PDGFRA) gene mutation has been shown to be a major force in GIST pathogenesis leading to down-stream phosphorylation of substrate proteins and subsequently activation of networks of signal transduction pathways that regulate cell proliferation, survival, apoptosis, motility and other important cell functions. Immunohistochemically, a great majority of GISTs show strong, diffuse c-kit expression. The diagnosis of GIST! is currently based on morphologic features and immunohistochemical demonstration of c-kit (CD117). However, in some cases c-kit immunoreactivity is weak or undetectable. Here we report a case of a c-kit negative mesenchymal neoplasm in which molecular analysis was required to establish the correct diagnosis of GIST. The synchronous appearance of c-kit positive GIST and other malignancies have been reported previously.3-6 To the best of our knowledge, this is the first report of a c-kit negative GIST of the stomach coexisting with a gastric adenocarcinoma
关键词	MUTATIONS DIAGNOSIS GISTS gastrointestinal stromal tumor gastric adenocarcinoma c-kit platelet-derived growth factor receptor alpha mutation
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4088815
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/142803
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院合肥物质科学研究院肿瘤医院
推荐引用方式 GB/T 7714	Zhang Hao,Zhang Shuilong,Xu Huimian. Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma[J]. CHINESE MEDICAL JOURNAL,2010,123(24):3728-3730.
APA	Zhang Hao,Zhang Shuilong,&Xu Huimian.(2010).Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma.CHINESE MEDICAL JOURNAL,123(24),3728-3730.
MLA	Zhang Hao,et al."Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma".CHINESE MEDICAL JOURNAL 123.24(2010):3728-3730.