| High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine | |
| Alternative Title | High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine |
| Lu Yi; Deng YiHui; Xu Huan; Shi Li; Dong XiaoHui; Li Le | |
| 2008 | |
| Source Publication | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| ISSN | 0253-3820 |
| Volume | 36Issue:9Pages:1265-1268 |
| Abstract | A method was established for the determination of docetaxel (DOC) in human serum albumin (HSA) nanoparticles by the addition of cysteine. The effect of cysteine (the disulphide bond breaker) on HSA disulphide bonds was monitored by the detection on the content of DOC from HSA-NP using HPLC. The measurements were performed on addition of 1 mu g/L free cysteine to the samples, the content assay of DOC were carried out after an incubation period of 30 min at 37 degrees C under continuous shaking. The results showed that the addition of cysteine significantly increased the release of DOC front HSA-NP, and the determination results of DOC were 10% higher than that of acetonitrile. |
| Keyword | HUMAN PLASMA PACLITAXEL ASSAY Cysteine disulphide bonds human serum albumin nanoparticle high performance liquid chromatography |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3399637 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142815 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Lu Yi,Deng YiHui,Xu Huan,et al. High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2008,36(9):1265-1268. |
| APA | Lu Yi,Deng YiHui,Xu Huan,Shi Li,Dong XiaoHui,&Li Le.(2008).High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,36(9),1265-1268. |
| MLA | Lu Yi,et al."High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 36.9(2008):1265-1268. |
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