High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine

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	High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine
其他题名	High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine
	Lu Yi; Deng YiHui; Xu Huan; Shi Li; Dong XiaoHui; Li Le
	2008
发表期刊	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN	0253-3820
卷号	36 期号:9 页码:1265-1268
摘要	A method was established for the determination of docetaxel (DOC) in human serum albumin (HSA) nanoparticles by the addition of cysteine. The effect of cysteine (the disulphide bond breaker) on HSA disulphide bonds was monitored by the detection on the content of DOC from HSA-NP using HPLC. The measurements were performed on addition of 1 mu g/L free cysteine to the samples, the content assay of DOC were carried out after an incubation period of 30 min at 37 degrees C under continuous shaking. The results showed that the addition of cysteine significantly increased the release of DOC front HSA-NP, and the determination results of DOC were 10% higher than that of acetonitrile.
关键词	HUMAN PLASMA PACLITAXEL ASSAY Cysteine disulphide bonds human serum albumin nanoparticle high performance liquid chromatography
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3399637
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/142815
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Lu Yi,Deng YiHui,Xu Huan,et al. High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2008,36(9):1265-1268.
APA	Lu Yi,Deng YiHui,Xu Huan,Shi Li,Dong XiaoHui,&Li Le.(2008).High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,36(9),1265-1268.
MLA	Lu Yi,et al."High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 36.9(2008):1265-1268.