IMR OpenIR
Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia
Alternative TitleBumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia
Xu Wangshu1; Sun Xuan3; Song Chengguang1; Mu Xiaopeng1; Ma Wenping5; Zhang Xinghu2; Zhao Chuansheng1
2016
Source PublicationNeural Regeneration Research
ISSN1673-5374
Volume11Issue:5Pages:745-751
AbstractBumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia. We established a rat model of cerebral ischemia by injecting endothelin-1 in the left cortical motor area and left corpus striatum. Seven days later, bumetanide 200 μg/kg/day was injected into the lateral ventricle for 21 consecutive days with a mini-osmotic pump. Results demonstrated that the number of neuroblasts cells and the total length of dendrites increased, escape latency reduced, and the number of platform crossings increased in the rat hippocampal dentate gyrus in the chronic stage of cerebral ischemia. These findings suggest that bumetanide promoted neural precursor cell regeneration, dendritic development and the recovery of cognitive function, and protected brain tissue in the chronic stage of ischemia.
Keywordnerve regeneration Neurology. Diseases of the nervous system RC346-429 cerebral ischemia bumetanide Na + -K + -2Cl- cotransporter 1 hippocampal dentate gyrus neurogenesis neural precursor cells dendritic development cognitive function neural regeneration
Indexed ByCSCD
Language英语
CSCD IDCSCD:5715079
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/142876
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Capital Med University, Beijing Tiantan Hosp, Dept Neurol, Neuroinfect & Neuroimmunol Ctr, Beijing, Peoples R China
3.Capital Med University, Beijing Tiantan Hosp, Dept Intervent Neuroradiol, Beijing, Peoples R China
4.China Med University, Benxi Cent Hosp, Dept Neurol, Benxi, Liaoning Provin, Peoples R China
5.北京大学
Recommended Citation
GB/T 7714
Xu Wangshu,Sun Xuan,Song Chengguang,et al. Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia[J]. Neural Regeneration Research,2016,11(5):745-751.
APA Xu Wangshu.,Sun Xuan.,Song Chengguang.,Mu Xiaopeng.,Ma Wenping.,...&Zhao Chuansheng.(2016).Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia.Neural Regeneration Research,11(5),745-751.
MLA Xu Wangshu,et al."Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia".Neural Regeneration Research 11.5(2016):745-751.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu Wangshu]'s Articles
[Sun Xuan]'s Articles
[Song Chengguang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu Wangshu]'s Articles
[Sun Xuan]'s Articles
[Song Chengguang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu Wangshu]'s Articles
[Sun Xuan]'s Articles
[Song Chengguang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.