| Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia | |
| Alternative Title | Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia |
| Xu Wangshu1; Sun Xuan3; Song Chengguang1; Mu Xiaopeng1; Ma Wenping5; Zhang Xinghu2; Zhao Chuansheng1 | |
| 2016 | |
| Source Publication | Neural Regeneration Research
 |
| ISSN | 1673-5374 |
| Volume | 11Issue:5Pages:745-751 |
| Abstract | Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia. We established a rat model of cerebral ischemia by injecting endothelin-1 in the left cortical motor area and left corpus striatum. Seven days later, bumetanide 200 μg/kg/day was injected into the lateral ventricle for 21 consecutive days with a mini-osmotic pump. Results demonstrated that the number of neuroblasts cells and the total length of dendrites increased, escape latency reduced, and the number of platform crossings increased in the rat hippocampal dentate gyrus in the chronic stage of cerebral ischemia. These findings suggest that bumetanide promoted neural precursor cell regeneration, dendritic development and the recovery of cognitive function, and protected brain tissue in the chronic stage of ischemia. |
| Keyword | nerve regeneration Neurology. Diseases of the nervous system RC346-429 cerebral ischemia bumetanide Na + -K + -2Cl- cotransporter 1 hippocampal dentate gyrus neurogenesis neural precursor cells dendritic development cognitive function neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:5715079 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142876 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Capital Med University, Beijing Tiantan Hosp, Dept Neurol, Neuroinfect & Neuroimmunol Ctr, Beijing, Peoples R China 3.Capital Med University, Beijing Tiantan Hosp, Dept Intervent Neuroradiol, Beijing, Peoples R China 4.China Med University, Benxi Cent Hosp, Dept Neurol, Benxi, Liaoning Provin, Peoples R China 5.北京大学 |
| Recommended Citation GB/T 7714 | Xu Wangshu,Sun Xuan,Song Chengguang,et al. Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia[J]. Neural Regeneration Research,2016,11(5):745-751. |
| APA | Xu Wangshu.,Sun Xuan.,Song Chengguang.,Mu Xiaopeng.,Ma Wenping.,...&Zhao Chuansheng.(2016).Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia.Neural Regeneration Research,11(5),745-751. |
| MLA | Xu Wangshu,et al."Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia".Neural Regeneration Research 11.5(2016):745-751. |
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