| A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy | |
| Alternative Title | A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy |
| Hua Wei1; Wang Dongmei1; Cai Lin1; Sun Chaofeng1; Fu Guosheng1; Wang Yutang1; Yan Ji1; Luo Zhiling1; Xu Jing1; Wang Zhiyong1; Xu Geng1; Shen Farong1; Xu Wei1; Wang Jingfeng1; Ren Xuejun1; Jin Wei1; Zhang Nan1; Lau Elizabeth OiYan1; Zhang Shu1 | |
| 2012 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 125Issue:3Pages:428-433 |
| Abstract | Background Cardiac resynchronization therapy (CRT) with biventricular pacing improves cardiac function, functional capacity and quality of life in selected patients with heart failure. The current study aimed to evaluate the efficacy of the intracardiac electrogram (IEGM)-based optimization method, QuickOpt (TM), in Chinese patients treated with CRT. |
| Other Abstract | Background Cardiac resynchronization therapy (CRT) with biventricular pacing improves cardiac function, functional capacity and quality of life in selected patients with heart failure. The current study aimed to evaluate the efficacy of the intracardiac electrogram (IEGM)-based optimization method, QuickOpt~(TM), in Chinese patients treated with CRT. Methods Aortic time velocity integrals (AVTI) achieved at the sensed atrioventricular (AV), paced AV and interventricular (VV) interval settings recommended by both QuickOpt~(TM) and standard echocardiographic optimization were measured in 101 patients. Consistency and the strength of the relationship between the two timing cycle optimization methods were assessed by intra-class correlation coefficient (ICC). Results The ICC showed good agreement and correlation with what the AVTI achieved at the optimal sensed AV (ICC=0.9683 (0.9535–0.9785)), paced AV (ICC=0.9642 (0.9475–0.9757)) and VV (ICC=0.9730 (0.9602–0.9817)) interval settings determined by the two optimization methods. The average time required by echocardiographic optimization and by QuickOpt~(TM) were (78.32±32.40) minutes and (1.98±1.64) minutes respectively (P <0.0001). Conclusion The QuickOpt~(TM) algorithm provides a quicker, simpler and reliable alternative to the standard method for timing cycle optimization. (ClinicalTrial.gov Reference Number: NCT00918294) |
| Keyword | SEVERE HEART-FAILURE DELAY OPTIMIZATION CONDUCTION DELAY VV-DELAY ECHO ECHOCARDIOGRAPHY TRIAL heart failure cardiac resynchronization therapy atrioventricular interval interventricular interval timing cycle optimization echocardiography aortic velocity time integral intracardiac electrogram QuickOpt (TM) |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [St. Jude Medical Inc.] ; [China Health & Medical Development Foundation] |
| CSCD ID | CSCD:4432881 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142932 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Peking Union Med Coll 2.Chinese Acad Med Sci Dept Cardiol Cardiovasc Institute 3.中国医学科学院 4.中国科学院金属研究所 5.Chongqing Med University 6.Xi An Jiao Tong University 7.浙江大学 8.中国人民解放军总医院 9.Anhui Prov Hosp 10.Kunming Med Coll 11.Tianjin Chest Hosp 12.Inner Mongolian Peoples Hosp 13.Zhejiang Hosp 14.南京大学 15.Sun Yat Sen University 16.Capital Med University 17.上海交通大学 |
| Recommended Citation GB/T 7714 | Hua Wei,Wang Dongmei,Cai Lin,et al. A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy[J]. CHINESE MEDICAL JOURNAL,2012,125(3):428-433. |
| APA | Hua Wei.,Wang Dongmei.,Cai Lin.,Sun Chaofeng.,Fu Guosheng.,...&Zhang Shu.(2012).A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy.CHINESE MEDICAL JOURNAL,125(3),428-433. |
| MLA | Hua Wei,et al."A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy".CHINESE MEDICAL JOURNAL 125.3(2012):428-433. |
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