| Micro—CT评价新型低弹β钛合金对动物骨质疏松性骨折愈合的影响 |
| 其他题名 | The application of micro-computed tomography （microCT） for the assessment of the effect of the new Iow elastic modulus β Ti alloy on bone healing of osteoporotic fracture in an animal model
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| 沙漠; 郭征; 付军; 李述军; 李靖; 张涌泉; 吴智刚; 袁超凡; 石磊; 王军
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| 2007
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| 发表期刊 | 中国骨质疏松杂志
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| ISSN | 1006-7108
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| 卷号 | 13.0期号:010页码:704-708 |
| 摘要 | 目的micro—CT评价新型低弹βB钛合金内植物对大鼠骨质疏松骨折愈合的作用及应力遮挡效应。方法SD雌性大鼠去势，建立骨质疏松动物模型，采用Utvag方法制备双股骨骨折模型，选用弹性模量分别为110GPa和30GPa的钛合金制成髓内针固定骨折，左侧为高弹组，右侧为低弹组，分别于术后2、4、6、12w行micro—CT测定，检测骨小梁的体积（BV）、样本体积（TV）、骨体积分数（BVF）、骨小梁间隙（Tb．Sp）、骨小梁厚度（Tb．Th）、骨小梁数（Tb．N）和结构模型指数（SMI）等指标，比较两种弹性模量钛合金植入物对骨折骨痂形成的影响，并进行统计学分析。结果骨质疏松大鼠股骨骨折后4w，兴趣区域1（ROI1）区，低弹组除TV、Tb．Sp高于高弹组外，BV、BVF、Tb，Th均低于高弹组；术后6w，ROI1区，低弹组TV值高于高弹组，其余差异无显著性；术后12w，ROI1区，低弹组TV、BV、Tb．N、Tb．Th、SMI均高于高弹组。ROI2区，低弹组BV、BVF、SMI均高于高弹组。结论新型低弹β钛合金内植物有利于大鼠骨质疏松骨折早期骨痂的形成，并提高骨折愈合的远期质量，减少了骨折固定节段的骨量丢失。 |
| 其他摘要 | Objective To investigate the influence of the low-modulus of elasticity （30 GPa） fixation on bone healing of osteoporotie fracture and the effects of stress shielding by miero-CT. Methods Thirty female Sprague- Dawley rats, aged 3 months, were selected, OVX was performed twelve weeks before femur fracture, the fracture of left femur was stabilized with the high-modulus of elasticity titanium alloy pin and the right with the low-modulus of elasticity. The bony calluses were observed miero-CT at two, four, six, and twelve weeks after fracture. The parameters included BV, TV, BVF, Tb. Th, Tb. N, Tb. Sp, SMI. Results The calluses at the low-modulus of elasticity group showed a significantly lower percentage of mineralized bone at 2 - 4 weeks postoperatively, and a higher amount of fibrous callus than the high-modulus of elasticity group. The calluses were no longer distinguishable at 6 - 9 weeks. The superior trabecular bone mierostructure was produced and less bone loss were shown under the low-modulus of elasticity pin at 12 weeks. Conclusion The new low elastic modulus β Ti alloy seemed to increase the fibrous callus formation at the initial phase, and improve the quality of bone healing at the later phase. |
| 关键词 | 弹性模量
钛合金
micro—CT
骨质疏松性骨折
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| 收录类别 | CSCD
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| 语种 | 中文
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| CSCD记录号 | CSCD:2978918
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.imr.ac.cn/handle/321006/143162
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| 专题 | 中国科学院金属研究所
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| 作者单位 | 中国科学院金属研究所
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推荐引用方式
GB/T 7714 |
沙漠,郭征,付军,等. Micro—CT评价新型低弹β钛合金对动物骨质疏松性骨折愈合的影响[J]. 中国骨质疏松杂志,2007,13.0(010):704-708.
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| APA |
沙漠.,郭征.,付军.,李述军.,李靖.,...&王军.(2007).Micro—CT评价新型低弹β钛合金对动物骨质疏松性骨折愈合的影响.中国骨质疏松杂志,13.0(010),704-708.
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| MLA |
沙漠,et al."Micro—CT评价新型低弹β钛合金对动物骨质疏松性骨折愈合的影响".中国骨质疏松杂志 13.0.010(2007):704-708.
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