含锌钙磷涂层种植体成骨性能的动物实验

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	含锌钙磷涂层种植体成骨性能的动物实验
其他题名	An experimental study of Zn/Ca/P-containing coatings on titanium implant surface modified by plasma electrolytic oxidation
	封伟 1; 赵宝红 2; 张伟 3; 蔺增 4
	2019
发表期刊	中华口腔医学杂志
ISSN	1002-0098
卷号	54.0 期号:1.0 页码:46-51
摘要	目的探讨等离子体电解氧化(plasma electrolytic oxidation,PEO)制备的含锌钙磷涂层种植体的成骨性能。方法应用PEO在钛种植体表面制备含锌钙磷涂层(含锌钙磷涂层组),并以不含锌的钙磷涂层种植体(钙磷涂层组)及喷砂酸蚀处理的钛种植体(喷砂组)作为对照。用随机数字表法将3组种植体(每组20枚)植于兔下颌骨双侧,分别于术后4、6、8、10、12周取材(每组每个时间点4枚种植体),进行种植体推出实验及种植体-骨断面形貌分析。结果含锌钙磷涂层呈多级孔洞状。各组种植体骨结合强度随时间增大,且术后各时间点3组差异均有统计学意义(P<0.05);术后12周种植体骨结合强度最大,含锌钙磷涂层组种植体骨结合强度(1.57±0.26)MPa显著大于喷砂组(0.83±0.24)MPa(P<0.05)。组织学观察及场发射扫描电镜结果显示,随时间增加,种植体表面附着的骨质增多,各时间点含锌钙磷涂层组新生骨量均多于其他两组。结论含锌钙磷涂层钛种植体可加速骨组织的形成和改建,提高种植体与骨组织的结合强度。
其他摘要	Objective To explore the osteogenic activity of Zn/Ca/P-containing coatings on titanium implant surface modified by plasma electrolytic oxidation (PEO).Methods Three groups implants including Zn/Ca/P-containing surface treated by PEO in experimental groups and Ca/P-containing and TiO2 sandblasted surface in control group were randomly inserted in the bilateral mandibular of rabbits. Mechanical testing and implant-bone interface observation were performed at 4, 6, 8, 10 and 12 weeks after implantion.Results Zn/Ca/P-containing coating presented a microporous structure. The push-out value indicated the statistical differences among the three groups at each observed time point (P<0.05), and implant-bone bonding power reached a maximum value at 12 weeks, those in the Zn/Ca/P-containing group (1.57±0.26) MPa was higher than those in the group with sandblasted surface (0.83±0.24) MPa (P<0.05). Histological examination and implant-bone interface observation using field scaning electron microscope (FSEM) showed that the new bone of implant-bone interface increased with healing time and the result from Zn/Ca/P-containing group was superior to that from the control groups at each observed time point.Conclusions Zn/Ca/P-containing coatings by PEO can accelerate bone formation and remodeling, and enhance bone-implant bonding force.
关键词	锌牙种植体骨整合等离子体电解氧化
收录类别	CSCD
语种	中文
CSCD记录号	CSCD:6410426
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/143252
专题	中国科学院金属研究所
作者单位	1.济宁医学院 2.中国医科大学 3.中国科学院金属研究所 4.东北大学
推荐引用方式 GB/T 7714	封伟,赵宝红,张伟,等. 含锌钙磷涂层种植体成骨性能的动物实验[J]. 中华口腔医学杂志,2019,54.0(1.0):46-51.
APA	封伟,赵宝红,张伟,&蔺增.(2019).含锌钙磷涂层种植体成骨性能的动物实验.中华口腔医学杂志,54.0(1.0),46-51.
MLA	封伟,et al."含锌钙磷涂层种植体成骨性能的动物实验".中华口腔医学杂志 54.0.1.0(2019):46-51.