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Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults
Alternative TitleDuration of hypertension is associated with cognitive function: a crosssectional study in Chinese adults
Li Tuo1; Bai Yu2; Xiang Junwu3; Wang Rui4; Bai Jie5; Tuo Xiping5; Zhao Zhongxin1
2014
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume127Issue:11Pages:2105-2110
AbstractBackground Hypertension (HTN) is a very prevalent public health problem and as the population ages, cognitive impairment (Cl) is also going to be a public health burden. However, the relationship between hypertension duration and cognitive function declination worldwide is still unknown. The aim of the study was to investigate the effects of HTN duration on CI in Chinese population.
Other AbstractBackground Hypertension (HTN) is a very prevalent public health problem and as the population ages, cognitive impairment (CI) is also going to be a public health burden. However, the relationship between hypertension duration and cognitive function declination worldwide is still unknown. The aim of the study was to investigate the effects of HTN duration on CI in Chinese population. Methods At baseline, 1 386 HTN patients and 293 normotensive (NT) people were enrolled. The HTN patients were further divided into four subgroups (duration of HTN 20 years) according to the HTN duration and were screened for cognitive function with neuropsychological tests including mini-mental-stateexamination (MMSE) and clock-drawing-test (CDT) in comparison with the NT group. Results More HTN patients had CI (45.3%) than NT subjects (30.4%), and increased with HTN duration (P <0.000 1). Compared with the scores of MMSE and CDT in the NT group, the declines were higher in the HTN patients (P <0.000 1), and in the four HTN subgroups, both MMSE and CDT scores fall when the HTN duration increased (P <0.05). Furthermore, in the HTN population without CI, the trend in alteration of CI was relatively mild but still existed (P <0.05). Conclusion People with HTN are more likely to have CI and the possibility and aggravation increases the prolongation of HTN duration, both in amnesic and nonamnesic function.
KeywordBLOOD-PRESSURE RISK-FACTORS IMPAIRMENT DEMENTIA METAANALYSIS ENTITY cognition impairment hypertension duration mini-mental-state-examination clock-drawing-test epidemiology
Indexed ByCSCD
Language英语
CSCD IDCSCD:5154423
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/143324
Collection中国科学院金属研究所
Affiliation1.上海长征医院
2.Changhai Hosp, Department Gastroenterol, Shanghai 200433, Peoples R China
3.中国科学院金属研究所
4.Second Mil Med University, Dept Hlth Stat, Shanhgai 200433, Peoples R China
5.Changhai Hosp, Department Geriatr, Shanghai 200433, Peoples R China
Recommended Citation
GB/T 7714
Li Tuo,Bai Yu,Xiang Junwu,et al. Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults[J]. CHINESE MEDICAL JOURNAL,2014,127(11):2105-2110.
APA Li Tuo.,Bai Yu.,Xiang Junwu.,Wang Rui.,Bai Jie.,...&Zhao Zhongxin.(2014).Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults.CHINESE MEDICAL JOURNAL,127(11),2105-2110.
MLA Li Tuo,et al."Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults".CHINESE MEDICAL JOURNAL 127.11(2014):2105-2110.
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